ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2015
Neural and Behavioral Correlates of Alcohol-Induced Aggression Under Provocation.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 51 citations in OpenAlex.
- Acute alcohol triggers rank-specific social ascent through a prefrontal-accumbens circuit in male mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Decoding the bidirectional links between alcohol misuse and aggression: toward a unified translational framework.Psychopharmacology · 2026Review
- Neurobiology of Aggression-Review of Recent Findings and Relationship with Alcohol and Trauma.Biology · 2023Review
- Activation of glucagon-like peptide-1 receptors reduces the acquisition of aggression-like behaviors in male mice.Translational psychiatry · 2022Article
- Dissociation of behavioral and neural responses to provocation during reactive aggression in healthy adults with high versus low externalization.Cognitive, affective & behavioral neuroscience · 2022Article
- The Interaction of Single Nucleotide Polymorphisms on Fibroblast Growth Factor 19 Superfamily Genes Is Associated With Alcohol Dependence-Related Aggression.Frontiers in genetics · 2021Article
- Punch-Drunk or Drunken Boxing? The Etiology of Alcohol-Related Physical Violence through Adolescence and Young Adulthood.Substance use & misuse · 2021Article
- Alcohol, Aggression, and Violence: From Public Health to Neuroscience.Frontiers in psychology · 2021Review
- Punishment on Pause: Preliminary Evidence That Mindfulness Training Modifies Neural Responses in a Reactive Aggression Task.Frontiers in behavioral neuroscience · 2021Article
- Impulsive and premeditated aggression in male offenders with antisocial personality disorder.PloS one · 2020Article
- RBFOX1, encoding a splicing regulator, is a candidate gene for aggressive behavior.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2020Review
- Habenula-prefrontal resting-state connectivity in reactive aggressive men - A pilot study.Neuropharmacology · 2019Article
- A Biobehavioral Validation of the Taylor Aggression Paradigm in Female Adolescents.Scientific reports · 2019Article
- Article
- A Role for Prefrontal Cortical NMDA Receptors in Murine Alcohol-Heightened Aggression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- The neural correlates of alcohol-related aggression.Cognitive, affective & behavioral neuroscience · 2018Article
- Neurocircuitry of aggression and aggression seeking behavior: nose poking into brain circuitry controlling aggression.Current opinion in neurobiology · 2018Review
- Aggression in Women: Behavior, Brain and Hormones.Frontiers in behavioral neuroscience · 2018Review
- A Review of Developmental Considerations in Human Laboratory Alcohol Research.Current addiction reports · 2017Article
- From provocation to aggression: the neural network.BMC neuroscience · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Although alcohol consumption is linked to increased aggression, its neural correlates have not directly been studied in humans so far. Based on a comprehensive neurobiological model of alcohol-induced aggression, we hypothesized that alcohol-induced aggression would go along with increased amygdala and ventral striatum reactivity and impaired functioning of the prefrontal cortex (PFC) under alcohol. We measured neural and behavioral correlates of alcohol-induced aggression in a provoking vs non-provoking condition with a variant of the Taylor aggression paradigm (TAP) allowing to differentiate between reactive (provoked) and proactive (unprovoked) aggression. In a placebo-controlled cross-over design with moderate alcohol intoxication (~0.6 g/kg), 35 young healthy adults performed the TAP during functional magnetic resonance imaging (fMRI). Analyses revealed that provoking vs non-provoking conditions and alcohol vs placebo increased aggression and decreased brain responses in the anterior cingulate cortex/dorso-medial PFC (provoking<non-provoking) and the ventral striatum (alcohol<placebo) across our healthy sample. Interestingly, alcohol specifically increased proactive (unprovoked) but not reactive (provoked) aggression (alcohol × provocation interaction). However, investigation of inter-individual differences revealed (1) that pronounced alcohol-induced proactive aggression was linked to higher levels of aggression under placebo, and (2) that pronounced alcohol-induced reactive aggression was related to increased amygdala and ventral striatum reactivity under alcohol, providing evidence for their role in human alcohol-induced reactive aggression. Our findings suggest that in healthy young adults a liability for alcohol-induced aggression in a non-provoking context might depend on overall high levels of aggression, but on alcohol-induced increased striatal and amygdala reactivity when triggered by provocation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.