Evidence map›Paper›PMID 25971461›Full record

ArticleClinical pediatrics2015

Opioid Prescribing and Potential Overdose Errors Among Children 0 to 36 Months Old.

William T Basco, Myla Ebeling, Sandra S Garner, Thomas C Hulsey, Kit Simpson

Abstract read
In one paragraph

Article in Clinical pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Acute opioid overdose in pediatric patients.Journal of the American College of Emergency Physicians open · 2024
    Article
  2. Annual Prevalence of Opioid Receipt by South Carolina Medicaid-Enrolled Children and Adolescents: 2000-2020.International journal of environmental research and public health · 2023
    Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

William T BascoMedical University of South Carolina, Charleston, SC, USA bascob@musc.edu.
Myla EbelingMedical University of South Carolina, Charleston, SC, USA.
Sandra S GarnerMedical University of South Carolina, Charleston, SC, USA.
Thomas C HulseyWest Virginia Unviversity, Morgantown, WV, USA.
Kit SimpsonMedical University of South Carolina, Charleston, SC, USA.

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI JUDITH FEINBERG · 2012 to 2026
$81.0M
SOUTH CAROLINA CLINICAL & TRANSLATIONAL RESEARCH INSTITUTE (SCTR)UL1RR029882 · NCRR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T. · 2009 to 2011
$10.1M
South Carolina Clinical & Translational Research Institute (SCTR)UL1TR000062 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T. · 2012 to 2014
$9.4M
Prescribing Errors in Ambulatory Pediatric CareK08HS015679 · AHRQ · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BASCO, WILLIAM T · 2006 to 2009
$508k
AHRQ HHS K08 HS015679AHRQ HHS K08HS015679NCATS NIH HHS UL1 TR000062NCATS NIH HHS UL1TR000062NCRR NIH HHS UL1 RR029882NCRR NIH HHS UL1RR029882NIGMS NIH HHS U54 GM104942
6 · The paper itself

Abstract

objectiveTo estimate the frequency of potential overdoses among outpatient opioid-containing prescriptions.

methodUsing 11 years of outpatient Medicaid prescription data, we compared opioid dose dispensed (observed) versus expected dose to estimate overdose error frequencies. A potential overdose was defined as any preparation dispensed that was >110% of expected based on imputed, 97th percentile weights.

resultsThere were 59 536 study drug prescriptions to children 0 to 36 months old. Overall, 2.7% of the prescriptions contained potential overdose quantities, and the average excess amount dispensed was 48% above expected. Younger ages were associated with higher frequencies of potential overdose. For example, 8.9% of opioid prescriptions among infants 0 to 2 months contained potential overdose quantities, compared with 5.7% among infants 3 to 5 months old, 3.6% among infants 6 to 11 months old, and 2.3% among children >12 months (P < .0001).

conclusionsOpioid prescriptions for infants and children routinely contained potential overdose quantities.

Indexed as

Analgesics, OpioidChild, PreschoolDrug OverdoseDrug PrescriptionsFemaleHumansInfantInfant, NewbornMaleMedicaidMedication ErrorsOutpatientsRetrospective StudiesSouth CarolinaUnited StatesAnalgesics, Opioidchildchildrenmedication errorsoverdosepatient safety

Identifiers

PMID25971461
PMCPMC4474749

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.