ArticleGenome biology and evolution2015
Inference of Evolutionary Forces Acting on Human Biological Pathways.
Article in Genome biology and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Global impact of micronutrients in modern human evolution.American journal of human genetics · 2025Article
- Evolutionary Changes in Pathways and Networks of Genes Expressed in the Brains of Humans and Macaques.Journal of molecular neuroscience : MN · 2021Article
- An epigenetic pathway in rice connects genetic variation to anaerobic germination and seedling establishment.Plant physiology · 2021Article
- Maintenance of Adaptive Dynamics and No Detectable Load in a Range-Edge Outcrossing Plant Population.Molecular biology and evolution · 2021Article
- Positive Selection in Gene Regulatory Factors Suggests Adaptive Pleiotropic Changes During Human Evolution.Frontiers in genetics · 2021Article
- Paternally Expressed Imprinted Genes under Positive Darwinian Selection in Arabidopsis thaliana.Molecular biology and evolution · 2019Article
- Examination of Signatures of Recent Positive Selection on Genes Involved in Human Sialic Acid Biology.G3 (Bethesda, Md.) · 2018Article
- Detection of Pathways Affected by Positive Selection in Primate Lineages Ancestral to Humans.Molecular biology and evolution · 2017Article
- Evolutionary and Topological Properties of Genes and Community Structures in Human Gene Regulatory Networks.PLoS computational biology · 2016Article
- Long-Distance Dispersal Shaped Patterns of Human Genetic Diversity in Eurasia.Molecular biology and evolution · 2016Article
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Authors and funding
4 authors.
Funding
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Abstract
Because natural selection is likely to act on multiple genes underlying a given phenotypic trait, we study here the potential effect of ongoing and past selection on the genetic diversity of human biological pathways. We first show that genes included in gene sets are generally under stronger selective constraints than other genes and that their evolutionary response is correlated. We then introduce a new procedure to detect selection at the pathway level based on a decomposition of the classical McDonald-Kreitman test extended to multiple genes. This new test, called 2DNS, detects outlier gene sets and takes into account past demographic effects and evolutionary constraints specific to gene sets. Selective forces acting on gene sets can be easily identified by a mere visual inspection of the position of the gene sets relative to their two-dimensional null distribution. We thus find several outlier gene sets that show signals of positive, balancing, or purifying selection but also others showing an ancient relaxation of selective constraints. The principle of the 2DNS test can also be applied to other genomic contrasts. For instance, the comparison of patterns of polymorphisms private to African and non-African populations reveals that most pathways show a higher proportion of nonsynonymous mutations in non-Africans than in Africans, potentially due to different demographic histories and selective pressures.
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