Trial reportDer Orthopade2015
[Endo-exo prostheses following limb-amputation].
Trial report in Der Orthopade, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Meta-analytic evaluation of complications and longevity of bone-anchored prostheses in lower extremity amputees: does design matter?Musculoskeletal surgery · 2026Pooled it
- Complications of bone-anchored prostheses for individuals with an extremity amputation: A systematic review.PloS one · 2018Pooled it
- Trial
- Breaking Barriers-The Promise and Challenges of Limb Osseointegration Surgery.Medicina (Kaunas, Lithuania) · 2025Article
- CORR Insights®: What Functional Outcomes Can Be Expected With Osseointegrated Prostheses in Transfemoral Amputations?Clinical orthopaedics and related research · 2025Article
- Lower Extremity Osseointegration Postoperative Rehabilitation Protocols: A Scoping Review.Physical therapy · 2025Article
- Management, outcome, and novel classification system of periprosthetic fractures in patients with transcutaneous osseointegrated prosthetic systems (TOPS)-a retrospective cohort analysis.Archives of orthopaedic and trauma surgery · 2022Article
- Twenty-four months of bacterial colonialization and infection rates in patients with transcutaneous osseointegrated prosthetic systems after lower limb amputation-A prospective analysis.Frontiers in microbiology · 2022Article
- [Transcutaneous osseointegrated prosthetic systems after major amputation of the lower extremity : A retrospective 3-year analysis].Der Orthopade · 2021Review
- Article
- Three-year follow-up of changes of cortical bone thickness after implantation of Endo-Exo-Prosthesis (EEP) for transfemoral amputees.Journal of orthopaedic surgery and research · 2020Article
- [The endo-exo prosthesis treatment concept : Improvement in quality of life after limb amputation].Der Unfallchirurg · 2017Review
- [Transcutaneous osseointegrated prosthesis (TOP) after limb amputation : Status quo and perspectives].Der Unfallchirurg · 2017Review
- [Function of prosthesis components in lower limb amputees with bone-anchored percutaneous implants : Biomechanical aspects].Der Unfallchirurg · 2017Article
- [Endo-exo prostheses : Osseointegrated percutaneously channeled implants for rehabilitation after limb amputation].Der Unfallchirurg · 2016Review
- Transtibial Osseointegration for Patients with Peripheral Vascular Disease: A Case Series of 6 Patients with Minimum 3-Year Follow-up.JB & JS open accessArticle
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveRehabilitation of patients having undergone limb amputation is difficult due to problems related to poor socket fit, which often deteriorates comfort, gait and the ability to take part in everyday life and work. The endo-exo prosthesis has been an alternative provision for people having undergone lower limb amputation for reasons other than diabetes or peripheral vascular disease for more than 10 years. The system consists of an intramedullar, osseointegrated and skin perforating prosthesis, which is implanted in the remaining bone and has an abutment to allow the attachment of the external prosthetic part including the knee joint in the case of a trans-femoral amputation. The idea originates in findings of modern tooth-implantology and involves a two-step operation. This study focuses on one centre's experience with the endo-exo prostheses in Lübeck, Germany, to describe and discuss the reliability of this alternative treatment method after lower limb amputation. MATERIALS AND
methodsThis article presents the results of lower limb amputees operated on in Lübeck, Germany between 1999-2013. It focuses on theoretical aspects of osseointegration and different clinically-based findings using the endo-exo technique over the last decade.
results74 lower-limb amputees were treated with an endo-exo prosthesis until December 2013. There were only 4 verified intramedullar infections, yet there were many unplanned surgical revisions secondary to soft-tissue infections in the beginning. They were successfully encountered via clinically-based changes that were made concerning implant design, wound treatment and operative technique.
conclusionsSince 1990 a few groups have developed an innovative method that provides an alternative to traditional socket-type prostheses. This involves a skeletally anchored device that is inserted into the remaining stump and provides osseointegration into the bone. The distal part of the implant protrudes transcutaneously and allows attachment to a prosthetic limb. This creates a hard point where the forces are transmitted through the skeleton with a more physiological pathway because the bone becomes the force carrier again, closer in biomechanics to an able-bodied person. With long-term numbers that show successful osseointegration for more than 10 years it is evident that obligate bacterial colonization does not necessarily lead to an intramedullar infection. Especially short stumps that are difficult to treat with a socket can be successfully fitted with an endo-exo prosthesis. Amputees who would otherwise be bound to a wheelchair due to their challenging situation should specifically be regarded as potential profiteers of this novel treatment option.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.