Evidence map›Paper›PMID 25970700›Full record

SynthesisScientific reports2015

A systematic review and meta-analysis of the effect of statins on plasma asymmetric dimethylarginine concentrations.

Corina Serban, Amirhossein Sahebkar, Sorin Ursoniu, Dimitri P Mikhailidis, Manfredi Rizzo, Gregory Y H Lip, G Kees Hovingh, John J P Kastelein, Leszek Kalinowski, Jacek Rysz and 1 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 21 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 21 pooled it
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 21 syntheses or guidelines pooled it, 184 citations in OpenAlex.

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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 7 countries.

Corina SerbanDepartment of Functional Sciences, Discipline of Pathophysiology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.ORCID 0000000333520398
Amirhossein Sahebkar1] Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran [2] Metabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia.
Sorin UrsoniuDepartment of Functional Sciences, Chair of Public Health, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
Dimitri P MikhailidisDepartment of Clinical Biochemistry, Royal Free Campus, University College London Medical School, University College London (UCL), London, UK.
Manfredi RizzoBiomedical Department of Internal Medicine and Medical Specialties, University of Palermo, Italy.
Gregory Y H LipUniversity of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, UK.
G Kees HovinghDepartment of Vascular Medicine, Academic Medical Center, Amsterdam, Netherlands.
John J P KasteleinDepartment of Vascular Medicine, Academic Medical Center, Amsterdam, Netherlands.
Leszek KalinowskiDepartment of Medical Laboratory Diagnostics, Medical University of Gdansk, Gdansk, Poland.
Jacek RyszDepartment of Nephrology, Hypertension and Family Medicine, Chair of Nephrology and Hypertension, Medical University of Lodz, Poland.
Maciej BanachDepartment of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Poland.
Amsterdam UMC Location University of Amsterdam · NLMedical University of Lodz · PLVictor Babeș University of Medicine and Pharmacy Timișoara · ROBirmingham City Hospital · GBGdańsk Medical University · PLMashhad University of Medical Sciences · IRThe Royal Free Hospital · GBUniversity of Palermo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The impact of statin therapy on plasma asymmetric dimethylarginine (ADMA) levels has not been conclusively studied. Therefore the aim of the meta-analysis was to assess the effect of statins on circulating ADMA levels. We searched selected databases (up to August 2014) to identify randomized controlled trials (RCTs) that investigate the effect of statins on plasma ADMA concentrations. A weighted meta-regression (WMD) using unrestricted maximum likelihood model was performed to assess the impact of statin dose, duration of statin therapy and baseline ADMA concentrations as potential variables on the WMD between statin and placebo group. In total, 1134 participants in 9 selected RCTs were randomized; 568 were allocated to statin treatment and 566 were controls. There was a significant reduction in plasma ADMA concentrations following statin therapy compared with placebo (WMD: -0.104 μM, 95% confidence interval: -0.131 to -0.077, Z = -7.577, p < 0.0001). Subgroups analysis has shown a significant impact of hydrophilic statins (WMD: -0.207 μM, 95%CI: -0.427 to +0.013, Z = -7.250, p < .0001) and a non-significant effect of hydrophobic statins (WMD: -0.101 μM, 95%CI: -0.128 to -0.074, Z = -1.845, p = 0.065). In conclusion, this meta-analysis of available RCTs showed a significant reduction in plasma ADMA concentrations following therapy with hydrophilic statins.

Indexed as

ArginineEndothelium, VascularHumansHydroxymethylglutaryl-CoA Reductase InhibitorsPublication BiasRandomized Controlled Trials as TopicArginineHydroxymethylglutaryl-CoA Reductase InhibitorsN,N-dimethylarginine

Identifiers

PMID25970700
PMCPMC4429557
OpenAlexW1572968453

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.