ArticlePloS one2015
Aging in Sensory and Motor Neurons Results in Learning Failure in Aplysia californica.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Age-related degradation of behavioral and network features ofFrontiers in aging neuroscience · 2026Article
- Age-related degradation of behavioral and network features ofbioRxiv : the preprint server for biology · 2025Article
- Host response to Aplysia Abyssovirus 1 in nervous system and gill.Developmental and comparative immunology · 2024Article
- Single-neuron analysis of aging-associated changes in learning reveals impairments in transcriptional plasticity.Aging cell · 2024Article
- Improvements in operant memory ofFrontiers in behavioral neuroscience · 2023Article
- An age-related decline in the cholinergic synaptic response may cause the firing pattern in the jaw-closing motor neurons, which resembles the aversive taste response in the feeding behavior of old Aplysia kurodai.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2022Article
- Aplysia Neurons as a Model of Alzheimer's Disease: Shared Genes and Differential Expression.Journal of molecular neuroscience : MN · 2022Article
- Structural aspects of the aging invertebrate brain.Cell and tissue research · 2021Review
- Co-expression analysis identifies neuro-inflammation as a driver of sensory neuron aging in Aplysia californica.PloS one · 2021Article
- FOXO Regulates Neuromuscular Junction Homeostasis DuringFrontiers in aging neuroscience · 2020Article
- Changes in Metabolism and Proteostasis Drive Aging Phenotype inFrontiers in aging neuroscience · 2020Article
- Ocean acidification affects acid-base physiology and behaviour in a model invertebrate, the California sea hare (Royal Society open science · 2019Article
- Workshop report: Cryopreservation of aquatic biomedical models.Cryobiology · 2019Article
- Altered expression of ionotropic L-Glutamate receptors in aged sensory neurons of Aplysia californica.PloS one · 2019Article
- Whole-transcriptome changes in gene expression accompany aging of sensory neurons in Aplysia californica.BMC genomics · 2018Article
- A comparison of hatchery-rearing in exercise to wild animal physiology and reflex behavior in Aplysia californica.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2018Article
- Phylogenetic analysis of ionotropic L-glutamate receptor genes in the Bilateria, with special notes on Aplysia californica.BMC evolutionary biology · 2017Article
- Habituation in the Tail Withdrawal Reflex Circuit is Impaired During Aging in Aplysia californica.Frontiers in aging neuroscience · 2016Article
- Age-related deficits in synaptic plasticity rescued by activating PKA or PKC in sensory neurons of Aplysia californica.Frontiers in aging neuroscience · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The physiological and molecular mechanisms of age-related memory loss are complicated by the complexity of vertebrate nervous systems. This study takes advantage of a simple neural model to investigate nervous system aging, focusing on changes in learning and memory in the form of behavioral sensitization in vivo and synaptic facilitation in vitro. The effect of aging on the tail withdrawal reflex (TWR) was studied in Aplysia californica at maturity and late in the annual lifecycle. We found that short-term sensitization in TWR was absent in aged Aplysia. This implied that the neuronal machinery governing nonassociative learning was compromised during aging. Synaptic plasticity in the form of short-term facilitation between tail sensory and motor neurons decreased during aging whether the sensitizing stimulus was tail shock or the heterosynaptic modulator serotonin (5-HT). Together, these results suggest that the cellular mechanisms governing behavioral sensitization are compromised during aging, thereby nearly eliminating sensitization in aged Aplysia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.