ArticlePloS one2015
Osteological, biomolecular and geochemical examination of an early anglo-saxon case of lepromatous leprosy.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Leprosy in skeletons from archaeological sites: A systematic review.PLoS neglected tropical diseases · 2025Pooled it
- Pathogen genomics study of an early medieval community in Germany reveals extensive co-infections.Genome biology · 2022Article
- Mycobacterium leprae diversity and population dynamics in medieval Europe from novel ancient genomes.BMC biology · 2021Article
- One Health Approaches to TraceFrontiers in microbiology · 2021Review
- Evaluating macroscopic sex estimation methods using genetically sexed archaeological material: The medieval skeletal collection from St John's Divinity School, Cambridge.American journal of physical anthropology · 2019Article
- Ancient genomes reveal a high diversity of Mycobacterium leprae in medieval Europe.PLoS pathogens · 2018Article
- Phylogenomics and antimicrobial resistance of the leprosy bacillus Mycobacterium leprae.Nature communications · 2018Article
- Leprosy at the edge of Europe-Biomolecular, isotopic and osteoarchaeological findings from medieval Ireland.PloS one · 2018Article
- Early Human Migrations (ca. 13,000 Years Ago) or Postcontact Europeans for the Earliest Spread ofInterdisciplinary perspectives on infectious diseases · 2017Review
- Investigation of a Medieval Pilgrim Burial Excavated from the Leprosarium of St Mary Magdalen Winchester, UK.PLoS neglected tropical diseases · 2017Article
- Exploring Relationships between Host Genome and Microbiome: New Insights from Genome-Wide Association Studies.Frontiers in microbiology · 2016Review
- Molecular studies on ancient M. tuberculosis and M. leprae: methods of pathogen and host DNA analysis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Review
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 2 countries.
Funding
Abstract
We have examined a 5th to 6th century inhumation from Great Chesterford, Essex, UK. The incomplete remains are those of a young male, aged around 21-35 years at death. The remains show osteological evidence of lepromatous leprosy (LL) and this was confirmed by lipid biomarker analysis and ancient DNA (aDNA) analysis, which provided evidence for both multi-copy and single copy loci from the Mycobacterium leprae genome. Genotyping showed the strain belonged to the 3I lineage, but the Great Chesterford isolate appeared to be ancestral to 3I strains found in later medieval cases in southern Britain and also continental Europe. While a number of contemporaneous cases exist, at present, this case of leprosy is the earliest radiocarbon dated case in Britain confirmed by both aDNA and lipid biomarkers. Importantly, Strontium and Oxygen isotope analysis suggest that the individual is likely to have originated from outside Britain. This potentially sheds light on the origins of the strain in Britain and its subsequent spread to other parts of the world, including the Americas where the 3I lineage of M. leprae is still found in some southern states of America.
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