ArticlePloS one2015
An elevated body mass index increases lung volume but reduces airflow in Italian schoolchildren.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Lung function in obese children and adolescents without respiratory disease: a systematic review.BMC pulmonary medicine · 2020Pooled it
- Assessment of ventilation distribution in overweight and obese children with asthma using electric impedance tomography: a cross-sectional study.Italian journal of pediatrics · 2026Article
- Risk factors for pulmonary function alterations in children with metabolic dysfunction-associated fatty liver disease.Scientific reports · 2025Article
- Longitudinal effects of obesity on pulmonary function in obese children and adolescents.Pediatric research · 2025Article
- Early-life and health behaviour influences on lung function in early adulthood.The European respiratory journal · 2023Article
- Assessing Respiratory Activity by Using IMUs: Modeling and Validation.Sensors (Basel, Switzerland) · 2022Article
- Obesity parameters in relation to lung function levels in a large Chinese rural adult population.Epidemiology and health · 2021Article
- Relationship of Nutritional Status and Spirometric Parameters in Children with Bronchial Asthma.Sovremennye tekhnologii v meditsine · 2021Article
- Causal Effects of Body Mass Index on Airflow Obstruction and Forced Mid-Expiratory Flow: A Mendelian Randomization Study Taking Interactions and Age-Specific Instruments Into Consideration Toward a Life Course Perspective.Frontiers in public health · 2021Article
- Variants in ADIPOQ gene are linked to adiponectin levels and lung function in young males independent of obesity.PloS one · 2020Article
- Low lung function in the developing world is analogous to stunting: a review of the evidence.Wellcome open research · 2020Article
- Metabolic syndrome and lung function in Korean children and adolescents: A cross-sectional study.Scientific reports · 2019Article
- Body mass index status and peripheral airway obstruction in school-age children: a population-based cohort study.Thorax · 2018Article
- Is obesity related to the lung function of non-asthmatic children?World journal of clinical pediatrics · 2018Review
- The associations between weight-related anthropometrics during childhood and lung function in late childhood: a retrospective cohort study.BMC pulmonary medicine · 2018Observational
- Which early life events or current environmental and lifestyle factors influence lung function in adolescents? - results from the GINIplus & LISAplus studies.Respiratory research · 2017Article
- The effect of scoliosis surgery on pulmonary function in spinal muscular atrophy type II patients.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2017Article
- Mediastinal pulmonary artery is associated with greater artery diameter and lingular division volume.Scientific reports · 2017Article
- The effect of obesity, weight gain, and weight loss on asthma inception and control.Current opinion in allergy and clinical immunology · 2017Review
- Obesity disproportionately impacts lung volumes, airflow and exhaled nitric oxide in children.PloS one · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAsthma and obesity are important and growing health issues worldwide. Obesity is considered a risk factor for asthma, due to the induction of changes in airway mechanics and altered airway inflammation.
methodsWe cross-sectionally investigated the effect of increased weight on pulmonary function in a large population sample of healthy children, aged 10-17 yrs living in Palermo, Italy. Explanatory effect of weight on lung function variables were evaluated by multiple linear regression models, taking into account height, gender, and age-class.
resultsAmong the 2,393 subjects, FVC and FEV1 were positively correlated to weight. Multiple regression models showed that the weight beta coefficient for FEV1 was significantly lower with respect to that for FVC (0.005 and 0.009 l/kg, respectively), indicating a different magnitude in explanatory effect of weight on FVC and FEV1. Both FEV1/FVC and FEF25-75%/FVC ratios were negatively correlated to weight, while FEF25-75% was not significantly correlated. Similar results were obtained also when 807 symptomatic subjects were introduced in the model through a sensitivity analysis.
conclusionIn healthy children, the disproportionate increase of FEV1 and FVC with weight produces airflow decrease and consequently apparent poorer lung function independently from respiratory disease status.
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