Evidence map›Paper›PMID 25970439›Full record

Trial reportPloS one2015

The effects of a calcium-rich pre-exercise meal on biomarkers of calcium homeostasis in competitive female cyclists: a randomised crossover trial.

Eric C Haakonssen, Megan L Ross, Emma J Knight, Louise E Cato, Alisa Nana, Anita E Wluka, Flavia M Cicuttini, Bing H Wang, David G Jenkins, Louise M Burke

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 6 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 6 syntheses or guidelines pooled it, 73 citations in OpenAlex.

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  10. Maintenance of Serum Ionized Calcium During Exercise Attenuates Parathyroid Hormone and Bone Resorption Responses.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Eric C HaakonssenSports Nutrition, Australian Institute of Sport, Belconnen, 2616, Australia; Physiology, Australian Institute of Sport, Belconnen, 2616, Australia; Human Movement Studies, University of Queensland, St Lucia, 4072, Australia.
Megan L RossSports Nutrition, Australian Institute of Sport, Belconnen, 2616, Australia; Physiology, Australian Institute of Sport, Belconnen, 2616, Australia.
Emma J KnightPerformance Research, Australian Institute of Sport, Belconnen, 2616, Australia.
Louise E CatoSports Nutrition, Australian Institute of Sport, Belconnen, 2616, Australia.
Alisa NanaSports Nutrition, Australian Institute of Sport, Belconnen, 2616, Australia.
Anita E WlukaDepartment of Epidemiology & Preventive Medicine, School of Public Health & Preventive Medicine, Monash University, Melbourne, 3004, Australia.
Flavia M CicuttiniDepartment of Epidemiology & Preventive Medicine, School of Public Health & Preventive Medicine, Monash University, Melbourne, 3004, Australia.
Bing H WangDepartment of Epidemiology & Preventive Medicine, School of Public Health & Preventive Medicine, Monash University, Melbourne, 3004, Australia.
David G JenkinsHuman Movement Studies, University of Queensland, St Lucia, 4072, Australia.
Louise M BurkeSports Nutrition, Australian Institute of Sport, Belconnen, 2616, Australia; School of Exercise Science, Australian Catholic University, Melbourne, 3065, Australia.
Australian Sports Commission · AUMonash University · AUUniversity of Queensland · AUAustralian Catholic University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cycling is recognised as a sport in which there is a high incidence of poor bone health. Sweat calcium losses may contribute to this. PURPOSE: To examine whether a calcium-rich pre-exercise meal attenuates exercise-induced perturbations of bone calcium homeostasis caused by maintenance of sweat calcium losses.

methodsUsing a randomized, counterbalanced crossover design, 32 well-trained female cyclists completed two 90 min cycling trials separated by 1 day. Exercise trials were preceded 2 hours by either a calcium-rich (1352 ± 53 mg calcium) dairy based meal (CAL) or a control meal (CON; 46 ± 7 mg calcium). Blood was sampled pre-trial; pre-exercise; and immediately, 40 min, 100 min and 190 min post-exercise. Blood was analysed for ionized calcium and biomarkers of bone resorption (Cross Linked C-Telopeptide of Type I Collagen (CTX-I), Cross Linked C-Telopeptide of Type II Collagen (CTX-II), Parathyroid Hormone (PTH), and bone formation (Procollagen I N-Terminal Propeptide (PINP)) using the established enzyme-linked immunosorbent assay technique.

resultsPTH and CTX-I increased from pre-exercise to post-exercise in both conditions but was attenuated in CAL (p < 0.001). PTH was 1.55 [1.20, 2.01] times lower in CAL immediately post-exercise and 1.45 [1.12, 1.88] times lower at 40 min post-exercise. CTX-I was 1.40 [1.15, 1.70] times lower in CAL at immediately post-exercise, 1.30 [1.07, 1.57] times lower at 40 min post-exercise and 1.22 [1.00, 1.48] times lower at 190 min post-exercise (p < 0.05). There was no significant interaction between pre-exercise meal condition and time point for CTX-II (p = 0.732) or PINP (p = 0.819).

conclusionThis study showed that a calcium-rich pre-exercise breakfast meal containing ~1350 mg of calcium consumed ~90 min before a prolonged and high intensity bout of stationary cycling attenuates the exercise induced rise in markers of bone resorption--PTH and CTX-I.

trial registrationAustralian New Zealand Clinical Trials Registry ACTRN12614000675628.

Indexed as

AthletesBicyclingAdolescentAdultBiomarkersBone ResorptionCalciumCalcium, DietaryCations, DivalentCollagen Type ICollagen Type IICross-Over StudiesDietExerciseFemaleHumansBiomarkersCalciumCalcium, DietaryCations, DivalentCollagen Type ICollagen Type IIcollagen type I trimeric cross-linked peptideParathyroid HormonePeptide FragmentsPeptidesProcollagenprocollagen Type I N-terminal peptide

Identifiers

PMID25970439
PMCPMC4430171
OpenAlexW2111104276

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.