Evidence map›Paper›PMID 25970296›Full record

ReviewGlia2015

Interplay between transcriptional control and chromatin regulation in the oligodendrocyte lineage.

Marylens Hernandez, Patrizia Casaccia

Abstract readReview
In one paragraph

Review in Glia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Oligodendrocyte progenitors as environmental biosensors.Seminars in cell & developmental biology · 2021
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. mNeuron · 2020
    Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Uncovering the Role of Sox2 in Oligodendroglia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Marylens HernandezDepartment of Neuroscience, Friedman Brain Institute and Icahn School of Medicine at Mount Sinai, New York City, New York.
Patrizia CasacciaDepartment of Neuroscience, Friedman Brain Institute and Icahn School of Medicine at Mount Sinai, New York City, New York.
Icahn School of Medicine at Mount Sinai · US

Funding

Role of cell cycle regulators in differentiationR01NS052738 · NINDS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI CANOLL, PETER, CASACCIA, PATRIZIA · 2007 to 2020
$4.6M
Histone Deacetylation in Oligodendrocyte DifferentiationR37NS042925 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CASACCIA, PATRIZIA · 2012 to 2018
$4.3M
Histone deacetylation in oligodendrocyte differentiationR01NS042925 · NINDS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI CASACCIA, PATRIZIA · 2003 to 2011
$3.9M
Nuclear Structure Reorganization During Oligodendrocyte DifferentiationF31NS083344 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HERNANDEZ, MARYLENS · 2013 to 2015
$81k
NINDS NIH HHS F31 NS083344NINDS NIH HHS F31NS083344NINDS NIH HHS R01 NS042925NINDS NIH HHS R01 NS052738NINDS NIH HHS R01-NS052738NINDS NIH HHS R37 NS042925NINDS NIH HHS R37-NS42925
6 · The paper itself

Abstract

The recent years have been characterized by a surge of studies on the role of transcription factors and histone modifications in regulating the progression of progenitors into oligodendrocytes. This review summarizes this body of evidence and presents an integrated view of transcriptional networks and epigenetic regulators defining proliferating progenitors and their differentiation along the oligodendrocyte lineage. We suggest that transcription factors in proliferating progenitors have direct access to DNA, due to predominantly euchromatic nuclei. As progenitors differentiate, however, transcriptional competence is modulated by the formation of heterochromatin, which modifies the association of DNA with nucleosomal histones and renders the access of transcription factors dependent on the activity of epigenetic modulators. These concepts are delineated within the context of development, and the potential functional implications are discussed.

Indexed as

AnimalsChromatinEpigenesis, GeneticHumansNeural Stem CellsOligodendrogliaTranscription FactorsChromatinTranscription Factorsbraindevelopmentepigenetichistonemyelin

Identifiers

PMID25970296
PMCPMC4470782
OpenAlexW1536007926

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.