ArticleKidney international2015
The mortality and hospitalization rates associated with the long interdialytic gap in thrice-weekly hemodialysis patients.
Article in Kidney international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
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42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- The effect of hyperkalemia and long inter-dialytic interval on morbidity and mortality in patients receiving hemodialysis: a systematic review.Renal failure · 2021Pooled it
- Renal Association Clinical Practice Guideline on Haemodialysis.BMC nephrology · 2019Guideline
- Trial
- Rationale and design for SHAREHD: a quality improvement collaborative to scale up Shared Haemodialysis Care for patients on centre based haemodialysis.BMC nephrology · 2017Trial
- Application of bioimpedance spectroscopy in Asian dialysis patients (ABISAD-III): a randomized controlled trial for clinical outcomes.International urology and nephrology · 2016Trial
- Article
- Relationship Between Timing of Hemodialysis and Procedure-Related Complications Following Endoscopy in Patients with End-Stage Renal Disease.Digestive diseases and sciences · 2025Article
- Using Ecological Momentary Assessment to Redefine Postdialysis Fatigue in Patients with Kidney Failure.Journal of the American Society of Nephrology : JASN · 2025Article
- The cardiovascular unphysiology of thrice weekly hemodialysis.Current opinion in nephrology and hypertension · 2025Review
- Emergency Department Use Among Adults Receiving Dialysis.JAMA network open · 2024Article
- Identification of patients undergoing chronic kidney replacement therapy in primary and secondary care data: validation study based on OpenSAFELY and UK Renal Registry.BMJ medicine · 2024Article
- Article
- Home dialysis therapies.Clinical medicine (London, England) · 2023Article
- Individualization of Serum-to-Dialysate Potassium Concentrations to Reduce the Risk of Sudden Cardiac Death Conferred by QT-Prolonging Antibiotics in Patients Receiving Hemodialysis.Kidney medicine · 2023Article
- Predictors of Urgent Dialysis Following Ambulance Transport to the Emergency Department in Patients Treated With Maintenance Hemodialysis.Canadian journal of kidney health and disease · 2023Article
- Digital health technology to support care and improve outcomes of chronic kidney disease patients: as a case illustration, the Withings toolkit health sensing tools.Frontiers in nephrology · 2023Review
- Higher Symptom Frequency and Severity After the Long Interdialytic Interval in Patients on Maintenance Intermittent Hemodialysis.Kidney international reports · 2022Article
- Article
- Cost of the quanta SC+ hemodialysis system for self-care in the United Kingdom.Hemodialysis international. International Symposium on Home Hemodialysis · 2022Review
- Patient Preferences for Longer or More Frequent In-Center Hemodialysis Regimens: A Multicenter Discrete Choice Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2022Article
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Authors and funding
5 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Excess mortality and hospitalization have been identified after the 2-day gap in thrice-weekly hemodialysis patients compared with 1-day intervals, although findings vary internationally. Here we aimed to identify factors associated with mortality and hospitalization events in England using an incident cohort of 5864 hemodialysis patients from years 2002 to 2006 inclusive in the UK Renal Registry linked to hospitalization data. Higher admission rates were seen after the 2-day gap irrespective of whether thrice-weekly dialysis sequence commenced on a Monday or Tuesday (2.4 per year after the 2-day gap vs. 1.4 for the rest of the week, rate ratio 1.7). The greatest differences in admission rates were seen in patients admitted with fluid overload or with conditions associated with a high risk of fluid overload. Increased mortality following the 2-day gap was similarly independent of session pattern (20.5 vs. 16.7 per 100 patient years, rate ratio 1.22), with these increases being driven by out-of-hospital death (rate ratio 1.59 vs. 1.06 for in-hospital death). Non-white patients had an overall survival advantage, with the increased mortality after the 2-day gap being found only in whites. Thus, fluid overload may increase the risk of hospital admission after the 2-day gap and that the increased out-of-hospital mortality may relate to a higher incidence of sudden death. Future work should focus on exploring interventions in these subgroups.
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