Evidence map›Paper›PMID 25970149›Full record

Trial reportNutrients2015

One Egg per Day Improves Inflammation when Compared to an Oatmeal-Based Breakfast without Increasing Other Cardiometabolic Risk Factors in Diabetic Patients.

Martha Nydia Ballesteros, Fabrizio Valenzuela, Alma E Robles, Elizabeth Artalejo, David Aguilar, Catherine J Andersen, Herlindo Valdez, Maria Luz Fernandez

Open access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 10 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 10 syntheses or guidelines pooled it, 74 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Martha Nydia BallesterosCentro de Investigacion y Desarrollo (CIAD), Hermosillo, Sonora, 83304, Mexico. nydia@ciad.mx.
Fabrizio ValenzuelaCentro de Investigacion y Desarrollo (CIAD), Hermosillo, Sonora, 83304, Mexico. fabe_vi@hotmail.com.
Alma E RoblesCentro de Investigacion y Desarrollo (CIAD), Hermosillo, Sonora, 83304, Mexico. melina@ciad.mx.
Elizabeth ArtalejoCentro de Investigacion y Desarrollo (CIAD), Hermosillo, Sonora, 83304, Mexico. eartalejo@ciad.mx.
David AguilarDepartment of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA. david_178@hotmail.com.
Catherine J AndersenDepartment of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA. candersen@fairfield.edu.
Herlindo ValdezHospital Ignacio Chavez, Hermosillo, Sonora, 83190, Mexico. herlindov@yahoo.com.mx.
Maria Luz FernandezDepartment of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA. maria-luz.fernandez@uconn.edu.
Centro de Investigación en Alimentación y Desarrollo · MXUniversity of Connecticut · USInstituto Nacional de Cardiología · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is concern that egg intake may increase blood glucose in patients with type 2 diabetes mellitus (T2DM). However, we have previously shown that eggs reduce inflammation in patients at risk for T2DM, including obese subjects and those with metabolic syndrome. Thus, we hypothesized that egg intake would not alter plasma glucose in T2DM patients when compared to oatmeal intake. Our primary endpoints for this clinical intervention were plasma glucose and the inflammatory markers tumor necrosis factor (TNF)-α and interleukin 6 (IL-6). As secondary endpoints, we evaluated additional parameters of glucose metabolism, dyslipidemias, oxidative stress and inflammation. Twenty-nine subjects, 35-65 years with glycosylated hemoglobin (HbA1c) values <9% were recruited and randomly allocated to consume isocaloric breakfasts containing either one egg/day or 40 g of oatmeal with 472 mL of lactose-free milk/day for five weeks. Following a three-week washout period, subjects were assigned to the alternate breakfast. At the end of each period, we measured all primary and secondary endpoints. Subjects completed four-day dietary recalls and one exercise questionnaire for each breakfast period. There were no significant differences in plasma glucose, our primary endpoint, plasma lipids, lipoprotein size or subfraction concentrations, insulin, HbA1c, apolipoprotein B, oxidized LDL or C-reactive protein. However, after adjusting for gender, age and body mass index, aspartate amino-transferase (AST) (p < 0.05) and tumor necrosis factor (TNF)-α (p < 0.01), one of our primary endpoints were significantly reduced during the egg period. These results suggest that compared to an oatmeal-based breakfast, eggs do not have any detrimental effects on lipoprotein or glucose metabolism in T2DM. In contrast, eggs reduce AST and TNF-α in this population characterized by chronic low-grade inflammation.

Indexed as

Diet, DiabeticEggsNutrition PolicyAdultAgedAvenaBreakfastCardiovascular DiseasesCross-Over StudiesDiabetes Mellitus, Type 2Diabetic AngiopathiesDiabetic CardiomyopathiesFemaleGlycated HemoglobinHumansInflammation MediatorsGlycated Hemoglobinhemoglobin A1c protein, humanInflammation MediatorsdiabeteseggsglucoseIL-6inflammationlipoproteinsTNF-α

Identifiers

PMID25970149
PMCPMC4446761
OpenAlexW2147848156

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.