ArticleThe Pediatric infectious disease journal2015
Bordetella pertussis is an uncommon pathogen in children hospitalized with bronchiolitis during the winter season.
Article in The Pediatric infectious disease journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 26 citations in OpenAlex.
- A new epidemic wave of Bordetella pertussis in paediatric population: impact and role of co-infections in pertussis disease.Italian journal of pediatrics · 2025Article
- Article
- Evaluation of BioFire Respiratory Panel 2Microbiology spectrum · 2023Article
- Etiologies of Hospitalized Acute Bronchiolitis in Children 2 Years of Age and Younger: A 3 Years' Study During aFrontiers in pediatrics · 2021Article
- Co-detection of Bordetella pertussis and other respiratory organisms in children hospitalised with lower respiratory tract infection.Scientific reports · 2020Article
- Multicenter Evaluation of BioFire FilmArray Respiratory Panel 2 for Detection of Viruses and Bacteria in Nasopharyngeal Swab Samples.Journal of clinical microbiology · 2018Article
- Bordetella and Bronchiolitis: A Chance Association or More Than That?Indian journal of pediatrics · 2018Article
- Infants hospitalized for Bordetella pertussis infection commonly have respiratory viral coinfections.BMC infectious diseases · 2017Article
- Epidemiology of pertussis in two Ibero-American countries with different vaccination policies: lessons derived from different surveillance systems.BMC public health · 2016Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundIn the United States (U.S.), Bordetella pertussis incidence has increased. Cough and apnea are common findings in pertussis and also in bronchiolitis, the most common cause of hospitalization in U.S. infants. The objective was to determine the prevalence of B. pertussis infection in children hospitalized with bronchiolitis and to describe its clinical course.
methodsChildren hospitalized with bronchiolitis and age <2 years were eligible for a prospective, multicenter cohort study during 3 consecutive winter seasons (November-March) from 2007 to 2010. Sixteen sites in 12 states participated using a standardized enrollment protocol. Families were asked the 2010 Centers for Disease Control and Prevention pertussis classification questions. Nasopharyngeal aspirates were obtained and tested by real-time polymerase chain reaction for 16 viruses, Mycoplasma pneumoniae and B. pertussis.
resultsTwo thousand sixty-eight (94%) of 2207 children had 1 or more respiratory pathogens. B. pertussis was identified in 4 children [0.2%; 95% confidence interval (CI): 0.1-0.5%] with 3 having a viral co-infection. All 4 were younger than 4 months; 2 met the Centers for Disease Control and Prevention definition of probable pertussis; and 3 had received at least 1 dose of an acellular pertussis vaccine. During the hospitalization, 2 had paroxysmal cough, 1 required intensive care unit care and the median length of stay was 13 days.
conclusionsOur data support that B. pertussis is an uncommon pathogen in U.S. children hospitalized with bronchiolitis in the winter. Making a diagnosis of pertussis can be challenging because the disease can be atypical and may not meet the Centers for Disease Control and Prevention definition of probable infection.
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