ArticlePhysical biology2015
Model for adhesion clutch explains biphasic relationship between actin flow and traction at the cell leading edge.
Article in Physical biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Mechanical observables of cancer invasion: actin, adhesion, and metastatic plasticity.Frontiers in cell and developmental biology · 2026Review
- Chemical compensation to mechanical loss in cell mechanosensation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The mechanism of dynamic steady states in lamellipodia.PLoS computational biology · 2025Article
- Cytoskeletal Proteins and Alzheimer's Disease Pathogenesis: Focusing on the Interplay with Tau Pathology.Biomolecules · 2025Review
- Cell-mechanical parameter estimation from 1D cell trajectories using simulation-based inference.PloS one · 2025Article
- A simple active fluid model unites cytokinesis, cell crawling, and axonal outgrowth.bioRxiv : the preprint server for biology · 2024Article
- A simple active fluid model unites cytokinesis, cell crawling, and axonal outgrowth.Frontiers in cell and developmental biology · 2024Article
- Mesenchymal cell migration on one-dimensional micropatterns.Frontiers in cell and developmental biology · 2024Review
- Force-dependent focal adhesion assembly and disassembly: A computational study.PLoS computational biology · 2023Article
- G-actin diffusion is insufficient to achieve F-actin assembly in fast-treadmilling protrusions.Biophysical journal · 2023Article
- Optimal cell traction forces in a generalized motor-clutch model.Biophysical journal · 2023Article
- A multi-scale clutch model for adhesion complex mechanics.PLoS computational biology · 2023Article
- Glioblastoma Spheroid Invasion through Soft, Brain-Like Matrices Depends on Hyaluronic Acid-CD44 Interactions.Advanced healthcare materials · 2023Article
- On the role of myosin-induced actin depolymerization during cell migration.Molecular biology of the cell · 2023Article
- On multistability and constitutive relations of cell motion on fibronectin lanes.Biophysical journal · 2023Article
- Deconstructing the role of myosin contractility in force fluctuations within focal adhesions.Biophysical journal · 2022Article
- Modeling cell protrusion predicts how myosin II and actin turnover affect adhesion-based signaling.Biophysical journal · 2022Article
- Discrete mechanical model of lamellipodial actin network implements molecular clutch mechanism and generates arcs and microspikes.PLoS computational biology · 2021Article
- Stick-slip model for actin-driven cell protrusions, cell polarization, and crawling.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Predicting Confined 1D Cell Migration from Parameters Calibrated to a 2D Motor-Clutch Model.Biophysical journal · 2020Article
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Authors and funding
4 authors.
Funding
Abstract
Cell motility relies on the continuous reorganization of a dynamic actin-myosin-adhesion network at the leading edge of the cell, in order to generate protrusion at the leading edge and traction between the cell and its external environment. We analyze experimentally measured spatial distributions of actin flow, traction force, myosin density, and adhesion density in control and pharmacologically perturbed epithelial cells in order to develop a mechanical model of the actin-adhesion-myosin self-organization at the leading edge. A model in which the F-actin network is treated as a viscous gel, and adhesion clutch engagement is strengthened by myosin but weakened by actin flow, can explain the measured molecular distributions and correctly predict the spatial distributions of the actin flow and traction stress. We test the model by comparing its predictions with measurements of the actin flow and traction stress in cells with fast and slow actin polymerization rates. The model predicts how the location of the lamellipodium-lamellum boundary depends on the actin viscosity and adhesion strength. The model further predicts that the location of the lamellipodium-lamellum boundary is not very sensitive to the level of myosin contraction.
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