ArticleJournal of osteoporosis2015
Association of MRS-Based Vertebral Bone Marrow Fat Fraction with Bone Strength in a Human In Vitro Model.
Article in Journal of osteoporosis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06216704 (Skeletal Health and Bone Marrow Composition in Adolescents With Cystic Fibrosis), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Skeletal Health and Bone Marrow Composition in Adolescents With Cystic Fibrosis
Who cites it
21 citing papers in PubMed.
- Article
- Article
- Associations of marrow fat fraction with MR imaging based trabecular bone microarchitecture in first-time diagnosed type 1 diabetes mellitus.Frontiers in endocrinology · 2024Article
- Association of lumbar vertebral bone marrow and paraspinal muscle fat composition with intervertebral disc degeneration: 3T quantitative MRI findings from the population-based KORA study.European radiology · 2023Article
- Quantitative MR Analysis of Changes in the Radius Bone Marrow in Osteoporosis.Journal of osteoporosis · 2023Article
- 3T-MRI-based age, sex and site-specific markers of musculoskeletal health in healthy children and young adults.Endocrine connections · 2022Article
- Opportunistic Use of Lumbar Magnetic Resonance Imaging for Osteoporosis Screening.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Article
- MR-based proton density fat fraction (PDFF) of the vertebral bone marrow differentiates between patients with and without osteoporotic vertebral fractures.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Article
- Changes in Vertebral Marrow Fat Fraction Using 3D Fat Analysis & Calculation Technique Imaging Sequence in Aromatase Inhibitor-Treated Breast Cancer Women.Frontiers in endocrinology · 2022Article
- Associations of incidental vertebral fractures and longitudinal changes of MR-based proton density fat fraction and T2* measurements of vertebral bone marrow.Frontiers in endocrinology · 2022Article
- Obesity and Bone: A Complex Relationship.International journal of molecular sciences · 2021Review
- Preclinical models for investigating how bone marrow adipocytes influence bone and hematopoietic cellularity.Best practice & research. Clinical endocrinology & metabolism · 2021Review
- Survey of MRI Usefulness for the Clinical Assessment of Bone Microstructure.International journal of molecular sciences · 2021Review
- Preliminary analysis of interaction of the fat fraction in the sacroiliac joint among sex, age, and body mass index in a normal Chinese population.The Journal of international medical research · 2020Article
- Reporting Guidelines, Review of Methodological Standards, and Challenges Toward Harmonization in Bone Marrow Adiposity Research. Report of the Methodologies Working Group of the International Bone Marrow Adiposity Society.Frontiers in endocrinology · 2020Review
- Vertebral Bone Marrow Heterogeneity Using Texture Analysis of Chemical Shift Encoding-Based MRI: Variations in Age, Sex, and Anatomical Location.Frontiers in endocrinology · 2020Article
- Vertebral bone marrow fat fraction changes in postmenopausal women with breast cancer receiving combined aromatase inhibitor and bisphosphonate therapy.BMC musculoskeletal disorders · 2019Observational
- Quantitative MRI and spectroscopy of bone marrow.Journal of magnetic resonance imaging : JMRI · 2018Review
- Anatomical Variation of Age-Related Changes in Vertebral Bone Marrow Composition Using Chemical Shift Encoding-Based Water-Fat Magnetic Resonance Imaging.Frontiers in endocrinology · 2018Article
- Measurement of vertebral bone marrow proton density fat fraction in children using quantitative water-fat MRI.Magma (New York, N.Y.) · 2017Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone marrow adiposity has recently gained attention due to its association with bone loss pathophysiology. In this study, ten vertebrae were harvested from fresh human cadavers. Trabecular BMD and microstructure parameters were extracted from MDCT. Bone marrow fat fractions were determined using single-voxel MRS. Failure load (FL) values were assessed by destructive biomechanical testing. Significant correlations (P < 0.05) were observed between MRS-based fat fraction and MDCT-based parameters (up to r = -0.72) and MRS-based fat fraction and FL (r = -0.77). These findings underline the importance of the bone marrow in the pathophysiology and imaging diagnostics of osteoporosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.