Evidence map›Paper›PMID 25969714›Full record

ArticleJournal of diabetes investigation2015

Association of variants in CDKN2A/2B and CDKAL1 genes with gestational insulin sensitivity and disposition in pregnant Han Chinese women.

Jie Mei, Shunyao Liao, Yunqiang Liu, Yuande Tan, Hailian Wang, Yaming Liang, Xianjue Dong, Wenzhong Song, Lu Gan, Shaoping Deng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes investigation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Ethnic Disparities in Gestational Diabetes.Current diabetes reports · 2018
    Review
  5. Article
  6. Article
  7. Review
  8. Erchen Decoction Prevents High-Fat Diet Induced Metabolic Disorders in C57BL/6 Mice.Evidence-based complementary and alternative medicine : eCAM · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Jie MeiDepartment of Obstetrics and Gynecology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China Chengdu, China.
Shunyao LiaoDiabetes Center & Institute of Transplantation, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China Chengdu, China.
Yunqiang LiuDepartment of Medical Genetics and Division of Morbid Genomics, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University Chengdu, China.
Yuande TanCollege of Life Science, Hunan Normal University Changsha, Hunan, China.
Hailian WangDiabetes Center & Institute of Transplantation, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China Chengdu, China.
Yaming LiangDiabetes Center & Institute of Transplantation, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China Chengdu, China.
Xianjue DongDiabetes Center & Institute of Transplantation, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China Chengdu, China.
Wenzhong SongDepartment of Nuclear Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China Chengdu, China.
Lu GanDiabetes Center & Institute of Transplantation, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China Chengdu, China.
Shaoping DengDiabetes Center & Institute of Transplantation, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China Chengdu, China ; Human Islet Laboratory, Massachusetts General Hospital, Harvard Medical School Boston, MA, USA.
University of Electronic Science and Technology of China · CNHunan Normal University · CNMassachusetts General Hospital · USSichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AIMS/

introductionVariants in cell cycle regulation genes, CDKAL1 and CDKN2A/2B, have been suggested to be associated with type 2 diabetes, and also play a role in insulin procession in non-diabetic European individuals. Rs7754580 in CDKAL1 and rs7020996 in CDKN2A/2B were found to be associated with gestational diabetes in Chinese individuals. In order to understand the metabolism mechanism of greatly upregulated maternal insulin signaling during pregnancy and the pathogenesis of gestational diabetes, we investigated the impact of rs7754580 and rs7020996 on gestational insulin regulation and procession. MATERIALS AND

methodsWe recruited 1,146 unrelated, non-diabetic, pregnant Han Chinese women (age 28.5 ± 4.1 years, body mass index 21.4 ± 2.6 kg/m(2)), and gave them oral glucose tolerance tests. The indices of insulin sensitivity, insulin disposition, insulin release and proinsulin to insulin conversion were calculated. Rs7754580 in the CDKAL1 gene and rs7020996 in the CDKN2A/2B gene were genotyped. Under an additive model, we analyzed the associations between the variants and gestational insulin indices using logistic regression.

resultsBy adjusting for maternal age, body mass index and the related interactions, CDKAL1 rs7754580 risk allele C was detected to be associated with increased insulin sensitivity (P = 0.011), decreased insulin disposition (P = 0.0002) and 2-h proinsulin conversion (P = 0.017). CDKN2A/2B rs7020996 risk allele T was found to be related to decreased insulin sensitivity (P = 0.002) and increased insulin disposition (P = 0.0001).

conclusionsThe study showed that cell cycle regulating genes might have a distinctive effect on gestational insulin sensitivity, β-cell function and proinsulin conversion in pregnant Han Chinese women.

Indexed as

Genetic associationGestational metabolismsInsulin index

Identifiers

PMID25969714
PMCPMC4420561
OpenAlexW2157667159

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.