ArticleMediators of inflammation2015
Decreased IL-27 Negatively Correlated with Th17 Cells in Non-Small-Cell Lung Cancer Patients.
Article in Mediators of inflammation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- MYC and KRAS cooperation: from historical challenges to therapeutic opportunities in cancer.Signal transduction and targeted therapy · 2024Review
- Interleukin-27 potentiates CD8+ T-cell-mediated antitumor immunity in chronic lymphocytic leukemia.Haematologica · 2023Article
- Relationship between Th17 immune response and cancer.World journal of clinical oncology · 2021Review
- Host Age and Denture Wearing Jointly Contribute to Oral Colonization with Intrinsically Azole-Resistant Yeasts in the Elderly.Microorganisms · 2021Article
- Interleukin-17 is associated with expression of programmed cell death 1 ligand 1 in ovarian carcinoma.Cancer science · 2019Article
- Serum Interleukin-27 Level in Different Clinical Stages of Lung Cancer.Open access Macedonian journal of medical sciences · 2019Article
- IL-27 inhibits non-small-cell lung cancer cell metastasis by miR-935 in vitro.OncoTargets and therapy · 2019Article
- Kras and Tumor Immunity: Friend or Foe?Cold Spring Harbor perspectives in medicine · 2018Review
- Th17, synchronically increased with TClinical and experimental immunology · 2018Article
- Retinoic Acid Receptor-Related Orphan Receptors: Critical Roles in Tumorigenesis.Frontiers in immunology · 2018Review
- Dual Roles of IL-27 in Cancer Biology and Immunotherapy.Mediators of inflammation · 2017Review
- High Interleukin 27 Production is Associated with Early Clinical Stage and Localized Disease in Patients with Melanoma.Journal of medical biochemistry · 2016Article
- [Role of Interleukin 17 in Lung Carcinogenesis and Lung Cancer Progression].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2016Review
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The presence of Th17 cells and IL-27 is observed in a variety of inflammatory associated cancers. However, there are some data on the role of Th17 cells and IL-27 in the regulation of immune reactions in non-small-cell lung cancer (NSCLC). The aim of this study is to assess the variation of Th17 cells and IL-27 in the peripheral blood (PB) of patients with NSCLC. The proportion of Th17 cells in peripheral blood mononuclear cells (PBMCs) was evaluated by flow cytometry. The serum concentrations of IL-27 and IL-17 were measured by enzyme-linked immunosorbent assay (ELISA). The mRNA expression of RORγt and IL-27 in the peripheral blood was examined by real-time quantitative polymerase chain reaction (QPCR). Expression of IL-27 was lower in NSCLC patients compared with normal controls. The frequency of Th17 cells was increased in NSCLC patients, accompanied by the upregulation of IL-17 and RORγt. IL-27 negatively correlated with the number of Th17 cells and the RORγt mRNA. Our results indicate that IL-27 might inhibit Th17 differentiation in NSCLC patients and better understanding of the regulatory effects of IL-27 on Th17 cells may shed light on potential new targets in cancer prevention and therapy.
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