ArticleThe Journal of infectious diseases2015
Gut Colonization of Healthy Children and Their Mothers With Pathogenic Ciprofloxacin-Resistant Escherichia coli.
Article in The Journal of infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Maternal gut microbiota in the postpartum Period: A Systematic review.European journal of obstetrics, gynecology, and reproductive biology · 2023Pooled it
- Fluoroquinolone resistance without fluoroquinolone use; the genie is truly out of the bottle.Frontiers in microbiology · 2026Review
- Phylogenetic groups and extraintestinal virulence genes of inflowMicrobiology (Reading, England) · 2025Article
- Comprehensive antibiotic resistome comparison ofCurrent research in microbial sciences · 2025Article
- Clonal and resistance profiles of fluoroquinolone-resistant uropathogenicFrontiers in microbiology · 2024Article
- Gastrointestinal Carriage of Antimicrobial Resistance in School-Aged Children in Three Municipalities of Timor-Leste.Antibiotics (Basel, Switzerland) · 2022Article
- Article
- Rare transmission of commensal and pathogenic bacteria in the gut microbiome of hospitalized adults.Nature communications · 2022Article
- Environmental Spread of Antibiotic Resistance.Antibiotics (Basel, Switzerland) · 2021Review
- Pharmacokinetics and pharmacodynamics of azithromycin in severe malaria bacterial co-infection in African children (TABS-PKPD): a protocol for a Phase II randomised controlled trial.Wellcome open research · 2021Article
- Plasmids shape the diverse accessory resistomes ofAccess microbiology · 2021Article
- Bacterial "Virulence" Traits and Host Demographics PredictOpen forum infectious diseases · 2020Article
- The Gut of Healthy Infants in the Community as a Reservoir of ESBL and Carbapenemase-Producing Bacteria.Antibiotics (Basel, Switzerland) · 2020Article
- Large Fecal Reservoir of Escherichia coli Sequence Type 131-H30 Subclone Strains That Are Shared Within Households and Resemble Clinical ST131-H30 Isolates.The Journal of infectious diseases · 2020Article
- Global Evolution of Pathogenic Bacteria With Extensive Use of Fluoroquinolone Agents.Frontiers in microbiology · 2020Article
- Article
- Persistent metagenomic signatures of early-life hospitalization and antibiotic treatment in the infant gut microbiota and resistome.Nature microbiology · 2019Article
- The pandemic Escherichia coli sequence type 131 strain is acquired even in the absence of antibiotic exposure.PLoS pathogens · 2019Review
- Antibiotic Resistance, Virulence Factors, Phenotyping, and Genotyping ofMicroorganisms · 2019Article
- "Enhanced acquisition of antibiotic-resistant intestinalAntimicrobial resistance and infection control · 2019Article
Corrections and comments
- Commented on by
Authors and funding
11 authors.
Funding
Abstract
backgroundThe reservoir of pathogenic ciprofloxacin-resistant Escherichia coli remains unknown.
methodsWe conducted a prospective cohort study of 80 healthy twins and their mothers to determine the frequency of excretion of ciprofloxacin-resistant, potentially pathogenic E. coli. Stool specimens were cultured selectively for ciprofloxacin-resistant gram-negative bacteria. Isolates were categorized on the basis of additional resistance and virulence profiles. We also prospectively collected clinical metadata.
resultsFifteen children (19%) and 8 mothers (20%) excreted ciprofloxacin-resistant E. coli at least once. Overall, 33% of 40 families had at least 1 member whose stool specimen yielded ciprofloxacin-resistant E. coli on culture. Fifty-seven submitted stool specimens (2.8%) contained such organisms; clones ST131-H30 and ST405 accounted for 52 and 5 of the positive specimens, respectively. Length of hospital stay after birth (P = .002) and maternal colonization (P = .0001) were associated with subsequent childhood carriage of ciprofloxacin-resistant E. coli; antibiotic use, acid suppression, sex, mode of delivery, and maternal perinatal antibiotic use were not. Ciprofloxacin-resistant E. coli were usually resistant to additional antibiotic classes, and all had virulence genotypes typical of extraintestinal pathogenic E. coli.
conclusionsHealthy children and their mothers commonly harbor ciprofloxacin-resistant E. coli with pathogenic potential.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.