ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2015
Variants in the Mannose-binding Lectin Gene MBL2 do not Associate With Sepsis Susceptibility or Survival in a Large European Cohort.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Host genetic variability and pneumococcal disease: a systematic review and meta-analysis.BMC medical genomics · 2019Pooled it
- Evaluation of Mannose Binding Lectin Gene Variants in Pediatric Influenza Virus-Related Critical Illness.Frontiers in immunology · 2019Trial
- Mannose-Binding Lectin Levels in Critically Ill Children With Severe Infections.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2017Trial
- Genomic and integrative based progression biomarker discovery in adult sepsis: toward clinical stratification and precision medicine.Annals of intensive care · 2026Review
- Host genetic variants associated with susceptibility and severity of pneumococcal pneumonia in adult patients.Pneumonia (Nathan Qld.) · 2023Article
- Mannose-binding lectin gene polymorphism in psoriasis and vitiligo: an observational study and computational analysis.Frontiers in medicine · 2023Article
- Association Between Variants of the Mannose-Binding Lectin 2 Gene and Susceptibility to Sepsis in the Hainan Island.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- Role ofDiagnostics (Basel, Switzerland) · 2022Article
- Levels of mannose-binding lectin (MBL) associates with sepsis-related in-hospital mortality in women.Journal of inflammation (London, England) · 2020Article
- Should MASP-2 Deficiency Be Considered a Primary Immunodeficiency? Relevance of the Lectin Pathway.Journal of clinical immunology · 2020Article
- Targeting the complement system in bacterial meningitis.Brain : a journal of neurology · 2019Review
- Methodological challenges in European ethics approvals for a genetic epidemiology study in critically ill patients: the GenOSept experience.BMC medical ethics · 2019Article
- Mannose-binding lectin and mannose-binding protein-associated serine protease 2 levels and infection in very-low-birth-weight infants.Pediatric research · 2018Article
- Sepsis 3 and the burns patient: do we need Sepsis 3.1?Scars, burns & healingArticle
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13 authors at 8 institutions in 3 countries.
Funding
Abstract
backgroundSepsis is an increasingly common condition, which continues to be associated with unacceptably high mortality. A large number of association studies have investigated susceptibility to, or mortality from, sepsis for variants in the functionally important immune-related gene MBL2. These studies have largely been underpowered and contradictory.
methodsWe genotyped and analyzed 4 important MBL2 single nucleotide polymorphisms (SNPs; rs5030737, rs1800450, rs1800451, and rs7096206) in 1839 European community-acquired pneumonia (CAP) and peritonitis sepsis cases, and 477 controls from the United Kingdom. We analyzed the following predefined subgroups and outcomes: 28-day and 6 month mortality from sepsis due to CAP or peritonitis combined, 28-day mortality from CAP sepsis, peritonitis sepsis, pneumococcal sepsis or sepsis in younger patients, and susceptibility to CAP sepsis or pneumococcal sepsis in the United Kingdom.
resultsThere were no significant associations (all P-values were greater than .05 after correction for multiple testing) between MBL2 genotypes and any of our predefined analyses.
conclusionsIn this large, well-defined cohort of immune competent adult patients, no associations between MBL2 genotype and sepsis susceptibility or outcome were identified.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.