Evidence map›Paper›PMID 25969469›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2015

Asymmetry in CT Scan Measures of Thigh Muscle 2 Months After Hip Fracture: The Baltimore Hip Studies.

Ram R Miller, Marty Eastlack, Gregory E Hicks, Dawn E Alley, Michelle D Shardell, Denise L Orwig, Bret H Goodpaster, Peter J Chomentowski, William G Hawkes, Marc C Hochberg and 2 more

RetractedAbstract readRetracted Publication
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Effects of Multicomponent Home-Based Intervention on Muscle Composition, Fitness, and Bone Density After Hip Fracture.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Ram R MillerGlaxoSmithKline, Research Triangle Park, North Carolina. Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine. ram.6.miller@gsk.com.
Marty EastlackDepartment of Physical Therapy, Arcadia University, Glenside, Pennsylvania.
Gregory E HicksDepartment of Physical Therapy, University of Delaware, Newark.
Dawn E AlleyDivision of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine.
Michelle D ShardellDivision of Biostatistics & Bioinformatics, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore.
Denise L OrwigDivision of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine.
Bret H GoodpasterTranslational Research Institute for Metabolism and Diabetes, Florida Hospital, Sanford Burnham Medical Research Institute, Orlando.
Peter J ChomentowskiDepartment of Kinesiology and Physical Education, Northern Illinois University, DeKalb.
William G HawkesDivision of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine.
Marc C HochbergDepartment of Medicine, University of Maryland School of Medicine, Baltimore.
Luigi FerrucciLongitudinal Studies Section, National Institute on Aging, Baltimore, Maryland.
Jay MagazinerDivision of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine.

Funding

University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI ALICE S. RYAN · 2006 to 2026
$28.9M
Sequelae of Hip Fracture in Men: An Epidemiologic StudyR37AG009901 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI MAGAZINER, JAY · 1992 to 2018
$11.3M
The Epidemiology of Bone Strength and Muscle Composition After Hip Fracture in MeR01AG029315 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI MAGAZINER, JAY · 2007 to 2011
$4.1M
Consequences of Inflammation on Muscle Following Hip FractureK23AG027746 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI MILLER, RAM R · 2008 to 2011
$646k
NIA NIH HHS K23AG027746NIA NIH HHS P30 AG028747NIA NIH HHS R01 AG029315NIA NIH HHS R37 AG09901
6 · The paper itself

Abstract

backgroundHip fracture is an important problem for older adults with significant functional consequences. After hip fracture, reduced muscle loading can result in muscle atrophy.

methodsWe compared thigh muscle characteristics in the fractured leg to those in the nonfractured leg in participants from the Baltimore Hip Studies 7th cohort using computed tomography scan imaging.

resultsAt 2 months postfracture, a single 10mm axial computed tomography scan was obtained at the midthigh level in 43 participants (23 men, 20 women) with a mean age of 79.9 years (range: 65-96 years), and thigh muscle cross-sectional area, cross-sectional area of intermuscular adipose tissue, and mean radiologic attenuation were measured. Total thigh muscle cross-sectional area was less on the side of the fracture by 9.46cm(2) (95% CI: 5.97cm(2), 12.95cm(2)) while the cross-sectional area of intermuscular adipose tissue was greater by 2.97cm(2) (95% CI: 1.94cm(2), 4.01cm(2)) on the fractured side. Mean muscle attenuation was lower on the side of the fracture by 3.66 Hounsfield Units (95% CI: 2.98 Hounsfield Units, 4.34 Hounsfield Units).

conclusionsThe observed asymmetry is consistent with the effect of disuse and inflammation in the affected limb along with training effects in the unaffected limb due to the favoring of this leg with ambulation during the postfracture period.

Indexed as

AgedAged, 80 and overBaltimoreFemaleHip FracturesHumansMaleMuscular AtrophyProspective StudiesQuadriceps MuscleTomography, X-Ray ComputedAgedComputed tomographyHip fractureMuscle composition

Identifiers

PMID25969469
PMCPMC4612358

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.