ArticleBMC evolutionary biology2015
Signatures of positive selection in the cis-regulatory sequences of the human oxytocin receptor (OXTR) and arginine vasopressin receptor 1a (AVPR1A) genes.
Article in BMC evolutionary biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Article
- Human cooperation and evolutionary transitions in individuality.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Oxytocin and vasotocin receptor variation and the evolution of human prosociality.Comprehensive psychoneuroendocrinology · 2022Article
- Did Dog Domestication Contribute to Language Evolution?Frontiers in psychology · 2021Article
- Factors affecting attitudes toward migrants-An evolutionary approach.American journal of human biology : the official journal of the Human Biology Council · 2021Article
- Williams Syndrome, Human Self-Domestication, and Language Evolution.Frontiers in psychology · 2019Article
- The AVPR1A Gene and Its Single Nucleotide Polymorphism rs10877969: A Literature Review of Associations with Health Conditions and Pain.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2018Review
- DNA polymorphism and selection at the bindin locus in three Strongylocentrotus sp. (Echinoidea).BMC genetics · 2016Article
- The Adapting Mind in the Genomic Era.Frontiers in psychology · 2016Review
- Implications of Oxytocin in Human Linguistic Cognition: From Genome to Phenome.Frontiers in neuroscience · 2016Article
- Trans-species polymorphism in humans and the great apes is generally maintained by balancing selection that modulates the host immune response.Human genomics · 2015Review
- Searching for ancient balanced polymorphisms shared between Neanderthals and Modern Humans.Genetics and molecular biologyArticle
- Oxytocin Modulation of Neural Circuits.Current topics in behavioral neurosciencesReview
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6 authors.
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Abstract
backgroundThe evolutionary highly conserved neurohypophyseal hormones oxytocin and arginine vasopressin play key roles in regulating social cognition and behaviours. The effects of these two peptides are meditated by their specific receptors, which are encoded by the oxytocin receptor (OXTR) and arginine vasopressin receptor 1a genes (AVPR1A), respectively. In several species, polymorphisms in these genes have been linked to various behavioural traits. Little, however, is known about whether positive selection acts on sequence variants in genes influencing variation in human behaviours.
resultsWe identified, in both neuroreceptor genes, signatures of balancing selection in the cis-regulative acting sequences such as transcription factor binding and enhancer sequences, as well as in a transcriptional repressor sequence motif. Additionally, in the intron 3 of the OXTR gene, the SNP rs59190448 appears to be under positive directional selection. For rs59190448, only one phenotypical association is known so far, but it is in high LD' (>0.8) with loci of known association; i.e., variants associated with key pro-social behaviours and mental disorders in humans.
conclusionsOnly for one SNP on the OXTR gene (rs59190448) was a sign of positive directional selection detected with all three methods of selection detection. For rs59190448, however, only one phenotypical association is known, but rs59190448 is in high LD' (>0.8), with variants associated with important pro-social behaviours and mental disorders in humans. We also detected various signatures of balancing selection on both neuroreceptor genes.
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