ArticleActa psychiatrica Scandinavica2016
Brain structural changes in schizoaffective disorder compared to schizophrenia and bipolar disorder.
Article in Acta psychiatrica Scandinavica, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Polysomnographic Parameters in Schizoaffective Disorder: A Systematic Review and Meta-Analysis.Alpha psychiatry · 2026Pooled it
- Morphometric Analysis of Structural MRI Using Schizophrenia Meta-analytic Priors Distinguish Patients from Controls in Two Independent Samples and in a Sample of Individuals With High Polygenic Risk.Schizophrenia bulletin · 2022Pooled it
- Neuroprotection after a first episode of mania: a randomized controlled maintenance trial comparing the effects of lithium and quetiapine on grey and white matter volume.Translational psychiatry · 2017Trial
- Psychiatric disorders in amyotrophic lateral sclerosis: a short note.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- The association between plasma betaine level and brain structural changes in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2025Article
- Molecular and micro-architectural mapping of gray matter alterations in psychosis.Molecular psychiatry · 2025Article
- Cortical morphometric similarity gradient in schizophrenia and its association with transcriptional profiles and clinical phenotype.Psychological medicine · 2025Article
- The relationship between schizophrenia or schizoaffective disorder and type 1 diabetes mellitus: a scoping review of observational studies.Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2024Article
- Developmental Predictors of Suicidality in Schizophrenia: A Systematic Review.Brain sciences · 2024Review
- The overlap across psychotic disorders: A functional network connectivity analysis.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2024Article
- Cortical anatomical variations, gene expression profiles, and clinical phenotypes in patients with schizophrenia.NeuroImage. Clinical · 2023Article
- Paliperidone to Treat Psychotic Disorders.Neurology international · 2021Review
- Childhood trauma, brain structure and emotion recognition in patients with schizophrenia and healthy participants.Social cognitive and affective neuroscience · 2020Article
- Identifying commonality and specificity across psychosis sub-groups via classification based on features from dynamic connectivity analysis.NeuroImage. Clinical · 2020Article
- Structural abnormality in schizophrenia versus bipolar disorder: A whole brain cortical thickness, surface area, volume and gyrification analyses.NeuroImage. Clinical · 2020Article
- Mapping Theme Trends and Knowledge Structure of Magnetic Resonance Imaging Studies of Schizophrenia: A Bibliometric Analysis From 2004 to 2018.Frontiers in psychiatry · 2020Article
- Morphometry and gyrification in bipolar disorder and schizophrenia: A comparative MRI study.NeuroImage. Clinical · 2020Article
- Psychiatric Symptoms in Amyotrophic Lateral Sclerosis: Beyond a Motor Neuron Disorder.Frontiers in neuroscience · 2019Review
- Abnormal levels of vascular endothelial biomarkers in schizophrenia.European archives of psychiatry and clinical neuroscience · 2018Article
- Multivariate Relationships Between Cognition and Brain Anatomy Across the Psychosis Spectrum.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018Article
Corrections and comments
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Authors and funding
20 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveBrain structural changes in schizoaffective disorder, and how far they resemble those seen in schizophrenia and bipolar disorder, have only been studied to a limited extent.
methodForty-five patients meeting DSM-IV and RDC criteria for schizoaffective disorder, groups of patients with 45 matched schizophrenia and bipolar disorder, and 45 matched healthy controls were examined using voxel-based morphometry (VBM).
resultsAnalyses comparing each patient group with the healthy control subjects found that the patients with schizoaffective disorder and the patients with schizophrenia showed widespread and overlapping areas of significant volume reduction, but the patients with bipolar disorder did not. A subsequent analysis compared the combined group of patients with the controls followed by extraction of clusters. In regions where the patients differed significantly from the controls, no significant differences in mean volume between patients with schizoaffective disorder and patients with schizophrenia in any of five regions of volume reduction were found, but mean volumes in the patients with bipolar disorder were significantly smaller in three of five.
conclusionThe findings provide evidence that, in terms of structural gray matter brain abnormality, schizoaffective disorder resembles schizophrenia more than bipolar disorder.
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