ArticleJournal of clinical laboratory analysis2016
Reticulocyte Hemoglobin Content During the First Month of Life in Critically Ill Very Low Birth Weight Neonates Differs From Term Infants, Children, and Adults.
Article in Journal of clinical laboratory analysis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Reference intervals for reticulocyte hemoglobin content in healthy infants.Pediatric research · 2018Trial
- Association between reticulocyte hemoglobin content (RetHe) and neurodevelopmental outcomes in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Prevalence and Predictors of Iron Deficiency at Hospital Discharge in Very-Low-Birth-Weight Infants: A Prospective Single-Center Observational Study Using RET-He and Serum Ferritin.Children (Basel, Switzerland) · 2026Article
- Reticulocyte hemoglobin equivalent as a diagnostic parameter of iron deficiency anemia in infants age 1-4 months.Archives of medical science : AMS · 2026Article
- Serum ferritin values in neonates <29 weeks' gestation are highly variable and do not correlate with reticulocyte hemoglobin content.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Ferritin in pediatric critical illness: a scoping review.Clinical and experimental pediatrics · 2023Article
- Prevalence and Implications of Low Reticulocyte-Hemoglobin Levels among Extreme Preterm Neonates: A Single-Center Retrospective Study.Nutrients · 2022Article
- Maternal diabetes and the role of neonatal reticulocyte hemoglobin content as a biomarker of iron status in the perinatal period.Frontiers in endocrinology · 2022Article
- Early iron supplementation and iron sufficiency at one month of age in NICU patients at-risk for iron deficiency.Blood cells, molecules & diseases · 2021Article
- Urinary ferritin; a potential noninvasive way to screen NICU patients for iron deficiency.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Reconciling markedly discordant values of serum ferritin versus reticulocyte hemoglobin content.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- How We Use Reticulocyte Parameters in Workup and Management of Pediatric Hematologic Diseases.Frontiers in pediatrics · 2020Article
- Trends in reticulocyte hemoglobin equivalent values in critically ill neonates, stratified by gestational age.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- Reference intervals for reticulocyte parameters of infants during their first 90 days after birth.Journal of perinatology : official journal of the California Perinatal Association · 2016Article
- Screening With Reticulocyte Hemoglobin Increased Iron Sufficiency Among NICU Patients.Pediatric quality & safetyArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundReticulocyte hemoglobin content (RET-He)-an established indicator of iron status in children and adults-was determined in very low birth weight (VLBW) infants.
methodsLongitudinal retrospective RET-He data in 26 VLBW neonates during the first month of age were compared with: (a) concurrent complete blood counts (CBCs), including hemoglobin (Hb) concentration, reticulocyte count, and immature reticulocyte fraction (IRF), and erythropoietin (EPO) levels; (b) clinical variables; and (c) RET-He data from the literature for term infants, children, and adults.
resultsRET-He within 24 hr following birth was 31.8 ± 1.1 pg (mean ± SEM). This was followed by an abrupt, significant decline to 28.3 ± 1.1 pg at 2-4 days, and to steady state levels of 28.4 ± 0.5 pg thereafter. The changes in RET-He were mirrored by changes in plasma EPO, reticulocyte count, and IRF, but not Hb. Steady state RET-He values after 4 days were significantly lower than RET-He values for term infants, children, and adults (31.6 ± 0.11, 32.0 ± 0.12, and 33.0 ± 0.13 pg, respectively).
conclusionAlthough RET-He values in VLBW infant were lower than term infants, children, and adults, the significance and mechanism(s) responsible are unknown. The present VLBW infant data are relevant to investigations assessing hemoglobinization following treatment with recombinant human EPO (r-HuEPO) and/or iron.
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