ArticleNature communications2015
Contrasting host-pathogen interactions and genome evolution in two generalist and specialist microsporidian pathogens of mosquitoes.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed.
- The shortest animal introns: insights from parasitic cnidarians.Molecular biology and evolution · 2026Article
- The Adult Aedes aegypti Bacterial Microbiota is Robust to Infection with the Obligate Microsporidian Parasite Edhazardia aedis.Environmental microbiology · 2026Article
- Microsporidia: evolution, infection mechanisms and host impact.Nature reviews. Microbiology · 2026Review
- Comprehensive analysis of small GTPases in Microsporidia reveals new extremes in eukaryotic cell biology.BMC biology · 2026Article
- Testing the redox theory of aging under parasitism.npj aging · 2026Article
- Forty new genomes shed light on sexual reproduction and the origin of tetraploidy in Microsporidia.PLoS biology · 2025Article
- Mechanisms of host exploitation by a microsporidian parasite.Proceedings. Biological sciences · 2025Article
- Insights to micropsoridia Nosema bombycis congenital infection and host immune responses in the embryo and larva stages of silkworms.BMC genomics · 2025Article
- Microsporidian infection of mosquito larvae changes the host-associated microbiome towards the synthesis of antimicrobial factors.Parasites & vectors · 2025Article
- Bioinformatics analysis of the Microsporidia sp. MB genome: a malaria transmission-blocking symbiont of the Anopheles arabiensis mosquito.BMC genomics · 2024Article
- Fungal pathogens and symbionts: Living off the fat of the land.PLoS pathogens · 2024Review
- An obligate microsporidian parasite modulates defense against opportunistic bacterial infection in the yellow fever mosquitomSphere · 2024Article
- Polyploidy is widespread in Microsporidia.Microbiology spectrum · 2024Article
- Treatment of MicrosporidiumMicroorganisms · 2024Article
- Functional annotation of a divergent genome using sequence and structure-based similarity.BMC genomics · 2024Article
- Nematocida displodere mechanosensitive ion channel of small conductance 2 assembles into a unique 6-channel super-structure in vitro.PloS one · 2024Article
- Near chromosome-level genome assembly of the microsporidium Hamiltosporidium tvaerminnensis.G3 (Bethesda, Md.) · 2023Article
- Genomic and phenotypic evolution of nematode-infecting microsporidia.PLoS pathogens · 2023Article
- Article
- A Putative TRAPα Protein of MicrosporidiaJournal of fungi (Basel, Switzerland) · 2023Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Obligate intracellular pathogens depend on their host for growth yet must also evade detection by host defenses. Here we investigate host adaptation in two Microsporidia, the specialist Edhazardia aedis and the generalist Vavraia culicis, pathogens of disease vector mosquitoes. Genomic analysis and deep RNA-Seq across infection time courses reveal fundamental differences between these pathogens. E. aedis retains enhanced cell surface modification and signalling capacity, upregulating protein trafficking and secretion dynamically during infection. V. culicis is less dependent on its host for basic metabolites and retains a subset of spliceosomal components, with a transcriptome broadly focused on growth and replication. Transcriptional profiling of mosquito immune responses reveals that response to infection by E. aedis differs dramatically depending on the mode of infection, and that antimicrobial defensins may play a general role in mosquito defense against Microsporidia. This analysis illuminates fundamentally different evolutionary paths and host interplay of specialist and generalist pathogens.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.