ArticleDevelopment (Cambridge, England)2015
Dynamics of the slowing segmentation clock reveal alternating two-segment periodicity.
Article in Development (Cambridge, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 72 citations in OpenAlex.
- Single-cell transcriptional dynamics in a living vertebrate.Cell systems · 2026Article
- Cycles upon cycles-Temperature scaling of medaka development.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The (un)likelihood of clock-driven lateral root priming; a modeling exploration.The Plant cell · 2026Article
- Article
- Substrate Rigidity Modulates Segmentation Clock Dynamics in Isolated Presomitic Mesoderm Cells.bioRxiv : the preprint server for biology · 2024Article
- Cellular and molecular control of vertebrate somitogenesis.Nature reviews. Molecular cell biology · 2024Review
- Article
- Ripply suppresses Tbx6 to induce dynamic-to-static conversion in somite segmentation.Nature communications · 2023Article
- Keeping development on time: Insights into post-transcriptional mechanisms driving oscillatory gene expression during vertebrate segmentation.Wiley interdisciplinary reviews. RNA · 2023Review
- Species-specific roles of the Notch ligands, receptors, and targets orchestrating the signaling landscape of the segmentation clock.Frontiers in cell and developmental biology · 2023Review
- Imaging the onset of oscillatory signaling dynamics during mouse embryo gastrulation.Development (Cambridge, England) · 2022Article
- Waves in Embryonic Development.Annual review of biophysics · 2022Review
- gga-miRNOME, a microRNA-sequencing dataset from chick embryonic tissues.Scientific data · 2022Article
- Article
- The vertebrate Embryo Clock: Common players dancing to a different beat.Frontiers in cell and developmental biology · 2022Review
- Patterning with clocks and genetic cascades: Segmentation and regionalization of vertebrate versus insect body plans.PLoS genetics · 2021Review
- Towards a physical understanding of developmental patterning.Nature reviews. Genetics · 2021Review
- Time and space in segmentation.Interface focus · 2021Article
- From local resynchronization to global pattern recovery in the zebrafish segmentation clock.eLife · 2021Article
- Molecular and Mechanical Cues for Somite Periodicity.Frontiers in cell and developmental biology · 2021Review
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
Abstract
The formation of reiterated somites along the vertebrate body axis is controlled by the segmentation clock, a molecular oscillator expressed within presomitic mesoderm (PSM) cells. Although PSM cells oscillate autonomously, they coordinate with neighboring cells to generate a sweeping wave of cyclic gene expression through the PSM that has a periodicity equal to that of somite formation. The velocity of each wave slows as it moves anteriorly through the PSM, although the dynamics of clock slowing have not been well characterized. Here, we investigate segmentation clock dynamics in the anterior PSM in developing zebrafish embryos using an in vivo clock reporter, her1:her1-venus. The her1:her1-venus reporter has single-cell resolution, allowing us to follow segmentation clock oscillations in individual cells in real-time. By retrospectively tracking oscillations of future somite boundary cells, we find that clock reporter signal increases in anterior PSM cells and that the periodicity of reporter oscillations slows to about ∼1.5 times the periodicity in posterior PSM cells. This gradual slowing of the clock in the anterior PSM creates peaks of clock expression that are separated at a two-segment periodicity both spatially and temporally, a phenomenon we observe in single cells and in tissue-wide analyses. These results differ from previous predictions that clock oscillations stop or are stabilized in the anterior PSM. Instead, PSM cells oscillate until they incorporate into somites. Our findings suggest that the segmentation clock may signal somite formation using a phase gradient with a two-somite periodicity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.