ArticleMedical science monitor : international medical journal of experimental and clinical research2015
Serum galectin-3 levels in children with chronic hepatitis B infection and inactive hepatitis B carriers.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- The Role of Oxidative Stress and Inflammatory Parameters in Heart Failure.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Galectins and Liver Diseases.International journal of molecular sciences · 2025Review
- Article
- The Pivotal Role of Galectin-3 in Viral Infection: A Multifaceted Player in Host-Pathogen Interactions.International journal of molecular sciences · 2023Review
- Galectin-3 as a Potential Prognostic Biomarker for COVID-19 Disease: A Case-Control Study.Cureus · 2022Article
- A Scoping Review of Galectin-3 as a Biomarker of Cardiovascular Diseases in Pediatric Populations.International journal of environmental research and public health · 2022Article
- Multiomics Analysis of Endocytosis upon HBV Infection and Identification of SCAMP1 as a Novel Host Restriction Factor against HBV Replication.International journal of molecular sciences · 2022Article
- Diagnostic Significance of Serum Galectin-3 in Hospitalized Patients with COVID-19-A Preliminary Study.Biomolecules · 2021Observational
- Molecular Identification and mRNA Expression Profiles of Galectin-9 Gene in Red Sea Bream (Animals : an open access journal from MDPI · 2021Article
- Role of Galectins in the Liver Diseases: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Article
- The roles of galectins in hepatic diseases.Journal of molecular histology · 2020Review
- Galectin-3 Stimulates Tyro3 Receptor Tyrosine Kinase and Erk Signalling, Cell Survival and Migration in Human Cancer Cells.Biomolecules · 2020Article
- Subclinical myocardial injury during vaso-occlusive crisis in pediatric sickle cell disease.European journal of pediatrics · 2018Article
- Galectin-3 levels relate in children to total body fat, abdominal fat, body fat distribution, and cardiac size.European journal of pediatrics · 2018Article
- Association of Serum Galectin-3 with the Acute Exacerbation of Chronic Obstructive Pulmonary Disease.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Serum Galectin-9 and Galectin-3-Binding Protein in Acute Dengue Virus Infection.International journal of molecular sciences · 2016Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic hepatitis B virus (HBV) infection is common worldwide. Follow-up of patients by the use of non-invasive techniques may be valuable in clinical practice. The aim of this study was to investigate serum galectin-3 (GAL-3) levels for monitoring disease status in children with chronic HBV infection. MATERIAL/
methodsThirty-two patients with chronic hepatitis B (CHB), 30 inactive HBV carrier patients, and 30 matched healthy controls were enrolled in the study. We performed basic laboratory tests: serum glucose, albumin, alanine aminotransferase (ALT), aspartate aminotransferase, gamma-glutamyl transferase (GGT), total bilirubin, prothrombin time, and activated partial thromboplastin time. In addition, serum GAL-3 levels were measured by ELISA technique.
resultsSignificantly higher serum GAL-3 levels (16.5±3.6, 1.1±0.3, 0.7±0.5 ng/ml, respectively, p<0.001) and ALT levels (80.2±30.6, 26.8±12.6, 28.1±4.4 IU/L, respectively, p<0.001) were found in the CHB group compared with the inactive carriers and the control groups. There were no significant differences in ALT levels and GAL-3 levels or between inactive HBV carriers and the control groups (p>0.05, for each). Significantly higher GGT levels were found in the CHB group (51.3±27.5 IU/L) compared with the inactive HBV carriers (35.7±10.1 IU/L) and the control group (31.3±9.5 IU/L) (p<0.001, and p=0.004, respectively). A significant correlation was found between GAL-3 and ALT levels in the CHB group (r=0.82, p<0.001).
conclusionsOur results suggest that serum GAL-3 level may be a beneficial indicator of chronicity in hepatitis B infection in children.
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