ArticleToxicology in vitro : an international journal published in association with BIBRA2015
Lead decreases cell survival, proliferation, and neuronal differentiation of primary cultured adult neural precursor cells through activation of the JNK and p38 MAP kinases.
Article in Toxicology in vitro : an international journal published in association with BIBRA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Chronic heavy metal exposure in Yunnan Province disrupts intestinal defenses and increases susceptibility to pathogens: an integrative review.Frontiers in public health · 2026Review
- Stem cell-based approaches for developmental neurotoxicity testing.Frontiers in toxicology · 2024Review
- Adolescent cadmium exposure impairs cognition and hippocampal neurogenesis in C57BL/6 mice.Environmental toxicology · 2022Article
- Heavy metals and adult neurogenesis.Current opinion in toxicology · 2021Article
- Cypermethrin Impairs Hippocampal Neurogenesis and Cognitive Functions by Altering Neural Fate Decisions in the Rat Brain.Molecular neurobiology · 2021Article
- From the low-density lipoprotein receptor-related protein 1 to neuropathic pain: a potentially novel target.Pain reports · 2021Review
- Low-level Lead Exposure Impairs Fronto-executive Functions: A Call to Update the DSM-5 with Lead Poisoning as a Neurodevelopmental Disorder.Psychology & neuroscience · 2020Article
- Developmental exposure to PbChemosphere · 2020Article
- Dusp4 Contributes to Anesthesia Neurotoxicity via Mediated Neural Differentiation in Primates.Frontiers in cell and developmental biology · 2020Article
- Cadmium Exposure Impairs Adult Hippocampal Neurogenesis.Toxicological sciences : an official journal of the Society of Toxicology · 2019Article
- Heavy Metal Neurotoxicants Induce ALS-Linked TDP-43 Pathology.Toxicological sciences : an official journal of the Society of Toxicology · 2019Article
- Cadmium Exposure Impairs Cognition and Olfactory Memory in Male C57BL/6 Mice.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
- Lead exposure in late adolescence through adulthood impairs short-term spatial memory and the neuronal differentiation of adult-born cells in C57BL/6 male mice.Neuroscience letters · 2017Article
- Cadmium impairs the survival and proliferation of cultured adult subventricular neural stem cells through activation of the JNK and p38 MAP kinases.Toxicology · 2017Article
- A path analysis of multiple neurotoxic chemicals and cognitive functioning in older US adults (NHANES 1999-2002).Environmental health : a global access science source · 2017Article
- Gene-environment interaction between lead and Apolipoprotein E4 causes cognitive behavior deficits in mice.Molecular neurodegeneration · 2017Article
- Methylglyoxal Causes Cell Death in Neural Progenitor Cells and Impairs Adult Hippocampal Neurogenesis.Neurotoxicity research · 2016Article
- Effects of addictive drugs on adult neural stem/progenitor cells.Cellular and molecular life sciences : CMLS · 2016Review
- Matching target dose to target organ.F1000Research · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Adult hippocampal neurogenesis is the process whereby adult neural precursor cells (aNPCs) in the subgranular zone (SGZ) of the dentate gyrus (DG) generate adult-born, functional neurons in the hippocampus. This process is modulated by various extracellular and intracellular stimuli, and the adult-born neurons have been implicated in hippocampus-dependent learning and memory. However, studies on how neurotoxic agents affect this process and the underlying mechanisms are limited. The goal of this study was to determine whether lead, a heavy metal, directly impairs critical processes in adult neurogenesis and to characterize the underlying signaling pathways using primary cultured SGZ-aNPCs isolated from adult mice. We report here that lead significantly increases apoptosis and inhibits proliferation in SGZ-aNPCs. In addition, lead significantly impairs spontaneous neuronal differentiation and maturation. Furthermore, we found that activation of the c-Jun NH2-terminal kinase (JNK) and p38 mitogen activated protein (MAP) kinase signaling pathways are important for lead cytotoxicity. Our data suggest that lead can directly act on adult neural stem cells and impair critical processes in adult hippocampal neurogenesis, which may contribute to its neurotoxicity and adverse effects on cognition in adults.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.