ReviewBMC cancer2015
Pazopanib for metastatic pulmonary epithelioid hemangioendothelioma-a suitable treatment option: case report and review of anti-angiogenic treatment options.
Review in BMC cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06680401 (The Evaluation of Cytokines and Hormones as Biomarkers for Epithelioid Haemangioendothelioma and Generation of Patient-derived Preclinical Models to Assess the Activity of Anticancer Agents and Validate Novel Therapeutic Targets), which is not on this map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Evaluation of Cytokines and Hormones as Biomarkers for Epithelioid Haemangioendothelioma and Generation of Patient-derived Preclinical Models to Assess the Activity of Anticancer Agents and Validate Novel Therapeutic Targets
Who cites it
36 citing papers in PubMed, 77 citations in OpenAlex.
- Pulmonary epithelioid hemangioendothelioma with pleural dissemination: a case report of prolonged diagnostic delay and the role of surgical biopsy.BMC pulmonary medicine · 2026Article
- Epithelioid hemangioendothelioma presenting as multiple pulmonary nodules following primary lung adenocarcinoma resection: a diagnostic challenge and clinical management dilemma.Journal of surgical case reports · 2026Article
- Epithelioid Hemangioendothelioma With a Novel Chromosomal Deletion and an Aggressive Clinical Course: A Case Report and Literature Review.Case reports in oncological medicine · 2026Article
- An extremely rare case of epithelioid hemangioendothelioma presumed metastasis to the pineal body.Surgical neurology international · 2025Article
- Pulmonary epithelioid hemangioendothelioma: a case report and review of literature.AME case reports · 2025Article
- Auricular epithelioid hemangioendothelioma: Two cases first diagnosed as auricular pseudocyst.Oncology letters · 2025Article
- Primary pulmonary epithelioid hemangioendothelioma.BMJ case reports · 2023Article
- Primary malignant epithelioid hemangioendothelioma of the pleura: A review and report of a novel case.Clinical case reports · 2022Article
- Advanced epithelioid hemangioendothelioma of the liver: could lenvatinib offer a bridge treatment to liver transplantation?Therapeutic advances in medical oncology · 2022Article
- Case report: Successful treatment with the combined therapy of interferon-alpha 2b and anlotinib in a patient with advanced hepatic epithelioid hemangioendothelioma.Frontiers in medicine · 2022Article
- Sirolimus combined with interferon-alpha 2b therapy for giant hepatic epithelioid hemangioendothelioma: a case report.Frontiers in oncology · 2022Article
- Review
- Systemic therapies in advanced epithelioid haemangioendothelioma: A retrospective international case series from the World Sarcoma Network and a review of literature.Cancer medicine · 2021Review
- Article
- Epithelioid hemangioendothelioma: evaluation byAmerican journal of nuclear medicine and molecular imaging · 2021Article
- Primary lung neoplasms presenting as multiple synchronous lung nodules.European respiratory review : an official journal of the European Respiratory Society · 2020Review
- Effective combined therapy for pulmonary epithelioid hemangioendothelioma: A case report.World journal of clinical cases · 2020Article
- Difficulty of treatment for pleural epithelioid hemangioendothelioma: a report of a case.General thoracic and cardiovascular surgery · 2020Article
- Metastatic Hepatic Epithelioid Hemangioendothelioma Treated with Olaratumab: A Falling Star Rising?Therapeutics and clinical risk management · 2020Article
- [Research Progress of Pulmonary Epithelioid Hemangioendothelioma].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEpithelioid hemangioendothelioma is a rare vascular tumor of borderline or low-grade malignancy. The lungs and liver are the two common primary organs affected. Metastatic disease was reported in more than 100 cases in the literature. However, no firm conclusions can be determined for recommended treatment options. CASE PRESENTATION: The current case presents a patient with metastatic pulmonary epithelioid hemangioendothelioma to the cervical and mediastinal lymph nodes, lungs and liver that has been treated with pazopanib for more than two years with PET avid complete metabolic response in the mediastinum and lungs, and long-lasting stable disease. Target therapies that block VEGFR have a logical base in this rare malignancy.
conclusionsThe current case is the first to report objective, long-lasting response to pazopanib.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.