ArticleChinese journal of integrative medicine2017
Chinese tuina downregulates the elevated levels of tissue plasminogen activator in sciatic nerve injured Sprague-Dawley rats.
Article in Chinese journal of integrative medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Effects of Tuina in Patients With Chronic Nonspecific Low Back Pain: A Randomized Controlled Trial.Journal of primary care & community healthTrial
- Chinese massage therapy (Tuina) inhibits motor neuron apoptosis in rats with sciatic nerve injury by regulating the cPLA2 and RhoA/ROCK2 signaling pathways.Frontiers in neurology · 2025Article
- Tuina alleviates the muscle atrophy induced by sciatic nerve injury in rats through regulation of PI3K/Akt signaling.Journal of orthopaedic surgery and research · 2024Article
- Exploring the Mechanism of Immediate Analgesia Induced by Tuina Intervention on Minor Chronic Constriction Injury in Rats Using LC-MS.Journal of pain research · 2024Article
- Brain plasticity after peripheral nerve injury treatment with massage therapy based on resting-state functional magnetic resonance imaging.Neural regeneration research · 2021Article
- A Review on the Mechanism of Tuina Promoting the Recovery of Peripheral Nerve Injury.Evidence-based complementary and alternative medicine : eCAM · 2021Review
- Efficacy of Tuina in patients with chronic low back pain: study protocol for a randomized controlled trial.Trials · 2020Article
- An Investigation into the Rehabilitative Mechanism of Tuina in the Treatment of Sciatic Nerve Injury.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Physiological Responses Induced by Manual Therapy in Animal Models: A Scoping Review.Frontiers in neuroscience · 2020Article
- Using RNA-Seq to Explore the Repair Mechanism of the Three Methods and Three-Acupoint Technique on DRGs in Sciatic Nerve Injured Rats.Pain research & management · 2020Article
- "Three Methods and Three Points" regulates p38 mitogen-activated protein kinase in the dorsal horn of the spinal cord in a rat model of sciatic nerve injury.Neural regeneration research · 2016Article
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo elucidate the mechanism of Chinese tuina in treating sciatic nerve crush injury, and to detect the levels of tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1), which is thought to play an important role in nerve regeneration.
methodsThirty-two adult male Sprague-Dawley rats were subjected to sciatic nerve crush injury and 16 rats (sham-operated group) went through a sham operation. Control group was given no treatment while tuina group received tuina therapy since day 7 post-surgery. Tuina treatment was performed once a day and lasted for 20 days. The sciatic functional index was examined every 5 days during the treatment session. The rats' gastrocnemius muscles were evaluated for changes in mass and immunohistochemistry techniques were performed to detect the levels of tPA and PAI-1.
resultsTuina therapy improved the motor function of sciatic nerve injured rats (P<0.05), however, it did not increase muscle volume (P<0.05). Tuina downregulated the levels of tPA and PAI-1 (P<0.05).
conclusionsThe present study implies that tuina treatment could accelerate rehabilitation of peripheral nerve injury.
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