Evidence map›Paper›PMID 25967575›Full record

Trial reportStroke2015

Perivascular adipose adiponectin correlates with symptom status of patients undergoing carotid endarterectomy.

Gaurav Sharma, Ming Tao, Kui Ding, David Yu, William King, Galina Deyneko, Xiaosong Wang, Alban Longchamp, Frederick J Schoen, C Keith Ozaki and 1 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Stroke, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05457881 (Short-Term Endogenous Hydrogen Sulfide Upregulation For Vein Graft Disease), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05457881 nawithdrawnnot on this mapstarted 2024, after this paper: background citation

Short-Term Endogenous Hydrogen Sulfide Upregulation For Vein Graft Disease

TypeinterventionalSponsorBrigham and Women's HospitalRan2024 to 2029Enrolled0ConditionsVascular Diseases, SurgeryArmsScandi-Shake
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Diabetes and carotid artery disease: a narrative review.Annals of translational medicine · 2020
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Gaurav SharmaFrom the Departments of Surgery (G.S., M.T., K.D., W.K., A.L., C.K.O., M.E.S.) and Pathology (F.J.S.), Brigham and Women's Hospital/Harvard Medical School, Boston, MA; University of Washington School of Medicine, Seattle, WA (D.Y.); and Novartis Institutes for BioMedical Research, Cambridge, MA (G.D., X.W.).
Ming TaoFrom the Departments of Surgery (G.S., M.T., K.D., W.K., A.L., C.K.O., M.E.S.) and Pathology (F.J.S.), Brigham and Women's Hospital/Harvard Medical School, Boston, MA; University of Washington School of Medicine, Seattle, WA (D.Y.); and Novartis Institutes for BioMedical Research, Cambridge, MA (G.D., X.W.).
Kui DingFrom the Departments of Surgery (G.S., M.T., K.D., W.K., A.L., C.K.O., M.E.S.) and Pathology (F.J.S.), Brigham and Women's Hospital/Harvard Medical School, Boston, MA; University of Washington School of Medicine, Seattle, WA (D.Y.); and Novartis Institutes for BioMedical Research, Cambridge, MA (G.D., X.W.).
David YuFrom the Departments of Surgery (G.S., M.T., K.D., W.K., A.L., C.K.O., M.E.S.) and Pathology (F.J.S.), Brigham and Women's Hospital/Harvard Medical School, Boston, MA; University of Washington School of Medicine, Seattle, WA (D.Y.); and Novartis Institutes for BioMedical Research, Cambridge, MA (G.D., X.W.).
William KingFrom the Departments of Surgery (G.S., M.T., K.D., W.K., A.L., C.K.O., M.E.S.) and Pathology (F.J.S.), Brigham and Women's Hospital/Harvard Medical School, Boston, MA; University of Washington School of Medicine, Seattle, WA (D.Y.); and Novartis Institutes for BioMedical Research, Cambridge, MA (G.D., X.W.).
Galina DeynekoFrom the Departments of Surgery (G.S., M.T., K.D., W.K., A.L., C.K.O., M.E.S.) and Pathology (F.J.S.), Brigham and Women's Hospital/Harvard Medical School, Boston, MA; University of Washington School of Medicine, Seattle, WA (D.Y.); and Novartis Institutes for BioMedical Research, Cambridge, MA (G.D., X.W.).
Xiaosong WangFrom the Departments of Surgery (G.S., M.T., K.D., W.K., A.L., C.K.O., M.E.S.) and Pathology (F.J.S.), Brigham and Women's Hospital/Harvard Medical School, Boston, MA; University of Washington School of Medicine, Seattle, WA (D.Y.); and Novartis Institutes for BioMedical Research, Cambridge, MA (G.D., X.W.).
Alban LongchampFrom the Departments of Surgery (G.S., M.T., K.D., W.K., A.L., C.K.O., M.E.S.) and Pathology (F.J.S.), Brigham and Women's Hospital/Harvard Medical School, Boston, MA; University of Washington School of Medicine, Seattle, WA (D.Y.); and Novartis Institutes for BioMedical Research, Cambridge, MA (G.D., X.W.).
Frederick J SchoenFrom the Departments of Surgery (G.S., M.T., K.D., W.K., A.L., C.K.O., M.E.S.) and Pathology (F.J.S.), Brigham and Women's Hospital/Harvard Medical School, Boston, MA; University of Washington School of Medicine, Seattle, WA (D.Y.); and Novartis Institutes for BioMedical Research, Cambridge, MA (G.D., X.W.).
C Keith OzakiFrom the Departments of Surgery (G.S., M.T., K.D., W.K., A.L., C.K.O., M.E.S.) and Pathology (F.J.S.), Brigham and Women's Hospital/Harvard Medical School, Boston, MA; University of Washington School of Medicine, Seattle, WA (D.Y.); and Novartis Institutes for BioMedical Research, Cambridge, MA (G.D., X.W.).
Marcus E SemelFrom the Departments of Surgery (G.S., M.T., K.D., W.K., A.L., C.K.O., M.E.S.) and Pathology (F.J.S.), Brigham and Women's Hospital/Harvard Medical School, Boston, MA; University of Washington School of Medicine, Seattle, WA (D.Y.); and Novartis Institutes for BioMedical Research, Cambridge, MA (G.D., X.W.). msemel1@partners.org.

Funding

ADVANCED TRAINING IN SURGICAL ONCOLOGYT32CA009535 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BUENO, RAPHAEL · 1985 to 2015
$3.5M
Harvard-Longwood Short-Term Research Training in Vascular SurgeryT35HL110843 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CHRISTIANE FERRAN, FRANK W LOGERFO · 2013 to 2026
$609k
NCI NIH HHS 5T32CA009535-26NCI NIH HHS T32 CA009535NHLBI NIH HHS 5T35HL110843NHLBI NIH HHS T35 HL110843
6 · The paper itself

Abstract

background and purposeRecent symptoms stand as a major determinant of stroke risk in patients with carotid stenosis, likely reflective of atherosclerotic plaque destabilization. In view of emerging links between vascular and adipose biology, we hypothesized that human perivascular adipose characteristics associate with carotid disease symptom status.

methodsClinical history, carotid plaques, blood, and subcutaneous and perivascular adipose tissues were prospectively collected from patients undergoing carotid endarterectomy. Nine adipose-associated biological mediators were assayed and compared in patients with symptomatic (n=15) versus asymptomatic (n=19) disease. Bonferroni correction was performed for multiple testing (α/9=0.006).

resultsSymptomatic patients had 1.9-fold higher perivascular adiponectin levels (P=0.005). Other circulating, subcutaneous, and perivascular biomarkers, as well as microscopic plaque characteristics, did not differ between symptomatic and asymptomatic patients.

conclusionsSymptomatic and asymptomatic carotid endarterectomy patients display a tissue-specific difference in perivascular adipose adiponectin. This difference, which was not seen in plasma or subcutaneous compartments, supports a potential local paracrine relationship with vascular disease processes that may be related to stroke mechanisms.

Indexed as

Carotid StenosisEndarterectomy, CarotidStrokeAdiponectinAgedBiomarkersFemaleHumansMaleMiddle AgedParacrine CommunicationPlaque, AtheroscleroticProspective StudiesRisk FactorsAdiponectinBiomarkersadipokinesadiponectinatherosclerosiscarotid stenosisendarterectomy, carotid

Identifiers

PMID25967575
PMCPMC4442051

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.