ArticlePsychosomatic medicine2015
Association between major depression and type 2 diabetes in midlife: findings from the Screening Across the Lifespan Twin Study.
Article in Psychosomatic medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Psychological and pharmacological interventions for depression in patients with coronary artery disease.The Cochrane database of systematic reviews · 2021Pooled it
- Understanding the relationship between type 2 diabetes and depression: lessons from genetically informative study designs.Diabetic medicine : a journal of the British Diabetic Association · 2021Pooled it
- Observational
- Understanding Suicide over the Life Course Using Data Science Tools within a Triangulation Framework.Journal of psychiatry and brain science · 2023Article
- Leveraging a genetically-informative study design to explore depression as a risk factor for type 2 diabetes: Rationale and participant characteristics of the Mood and Immune Regulation in Twins Study.Frontiers in clinical diabetes and healthcare · 2023Article
- Comorbidity of NovelInternational journal of molecular sciences · 2022Article
- Review
- Affective Temperament and Glycemic Control - The Psychological Aspect of Obesity and Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Glucose status and depressive symptoms: a cohort study of elderly people in northwest Finland.Scandinavian journal of primary health care · 2019Article
- Bivariate Genome-Wide Association Study of Depressive Symptoms With Type 2 Diabetes and Quantitative Glycemic Traits.Psychosomatic medicine · 2018Article
- Investigating shared aetiology between type 2 diabetes and major depressive disorder in a population based cohort.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Article
- A Longitudinal Relationship Between Depressive Symptoms and Development of Metabolic Syndrome: The Coronary Artery Risk Development in Young Adults Study.Psychosomatic medicine · 2016Article
- Genetic overlap between type 2 diabetes and depression in Swedish and Danish twin registries.Molecular psychiatry · 2016Article
- Placental, Matrilineal, and Epigenetic Mechanisms Promoting Environmentally Adaptive Development of the Mammalian Brain.Neural plasticity · 2016Review
- Genetic Overlap Between Type 2 Diabetes and Depression in a Sri Lankan Population Twin Sample.Psychosomatic medicineArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveCohort studies suggest that the relationship between major depression (MD) and Type 2 diabetes (T2DM) is bidirectional. However, this association may be confounded by shared genetic or environmental factors. The objective of this study was to use a twin design to investigate the association between MD and T2DM.
methodsData come from the Screening Across the Lifespan Twin Study, a sample of monozygotic and dizygotic twins 40 years or older sampled from the Swedish Twin Registry (n = 37,043). MD was assessed by using the Composite International Diagnostic Inventory. Structural equation twin modeling and Cox proportional hazards modeling were used to assess the relationship between MD and T2DM.
resultsApproximately 19% of respondents had a history of MD and 5% had a history of T2DM. MD was associated with 32% increased likelihood of T2DM (95% confidence interval = 1.00-1.80) among twins aged 40 to 55 years, even after accounting for genetic risk, but was not associated with T2DM among twins older than 55 years. T2DM was associated with 33% increased likelihood of MD (95% confidence interval = 1.02-1.72) among younger, but not older twins. Cholesky decomposition twin modeling indicated that common unique environmental factors contribute to the association between MD and T2DM.
conclusionsEnvironmental factors that are unique to individuals (i.e., not shared within families) but common to both MD and T2DM contribute to their co-occurrence in midlife. However, we cannot exclude the possibility of bidirectional causation as an alternate explanation. It is likely that multiple processes are operating to effect the relation between psychiatric and medical conditions in midlife.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.