Evidence map›Paper›PMID 25967270›Full record

Trial reportJournal of acquired immune deficiency syndromes (1999)2015

Brief Intervention Decreases Drinking Frequency in HIV-Infected, Heavy Drinking Women: Results of a Randomized Controlled Trial.

Geetanjali Chander, Heidi E Hutton, Bryan Lau, Xiaoqiang Xu, Mary E McCaul

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of acquired immune deficiency syndromes (1999), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03845205 (Alcohol Treatment Outcomes Following Early vs. Standard Liver Transplant for Severe Alcoholic Hepatitis), which is not on this map. Cited by 68 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 4 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03845205 narecruitingnot on this mapstarted 2020, after this paper: background citation

Alcohol Treatment Outcomes Following Early vs. Standard Liver Transplant for Severe Alcoholic Hepatitis (SAH)

TypeinterventionalSponsorJohns Hopkins UniversityRan2020 to 2027Enrolled200ConditionsAlcohol Use Disorder, Alcoholic HepatitisArmsIntegrated AUD Treatment
3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 4 syntheses or guidelines pooled it, 84 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Effectiveness of brief alcohol interventions in primary care populations.The Cochrane database of systematic reviews · 2018
    Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Geetanjali ChanderDepartments of *Medicine; †Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD; and ‡Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Heidi E Hutton
Bryan Lau
Xiaoqiang Xu
Mary E McCaul
Johns Hopkins University · USJohns Hopkins Medicine · US

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0M
3/4 Alcohol Research Consortium in HIV - Epidemiological Research Arm (ARCH-ERA)U01AA020793 · NIAAA · UNIVERSITY OF WASHINGTON · PI CRANE, HEIDI M., LAU, BRYAN · 2011 to 2020
$5.8M
Computerized BI for Binge Drinking HIV At-Risk & Infected African-American WomenR01AA018632 · NIAAA · JOHNS HOPKINS UNIVERSITY · PI CHANDER, GEETANJALI · 2009 to 2013
$2.1M
Brief Alcohol Intervention in HIV+ WomenR01AA014500 · NIAAA · JOHNS HOPKINS UNIVERSITY · PI MCCAUL, MARY E · 2003 to 2007
$1.7M
Alcohol and Psychiatric Comorbidity in HIV+ WomenK23AA015313 · NIAAA · JOHNS HOPKINS UNIVERSITY · PI CHANDER, GEETANJALI · 2005 to 2009
$875k
NIAAA NIH HHS K23 AA015313NIAAA NIH HHS K23AA015313NIAAA NIH HHS R01 AA014500NIAAA NIH HHS R01 AA018632NIAAA NIH HHS U01 AA020793NIAID NIH HHS P30 AI094189
6 · The paper itself

Abstract

objectiveHazardous alcohol use by HIV-infected women is associated with poor HIV outcomes and HIV transmission risk behaviors. We examined the effectiveness of brief alcohol intervention (BI) among hazardous drinking women receiving care in an urban HIV clinic.

methodsWomen were randomized to a 2-session BI or usual care. Outcomes assessed at baseline, 3, 6, and 12 months included 90-day frequency of any alcohol use and heavy/binge drinking (≥4 drinks per occasion), and average drinks per drinking episode. Secondary outcomes included HIV medication and appointment adherence, HIV-1 RNA suppression, and days of unprotected vaginal sex. We examined intervention effectiveness using generalized mixed-effect models and quantile regression.

resultsOf 148 eligible women, 74 were randomized to each arm. In mixed-effects models, 90-day drinking frequency decreased among intervention group compared with control, with women in the intervention condition less likely to have a drinking day (odds ratio: 0.42; 95% confidence interval: 0.23 to 0.75). Heavy/binge drinking days and drinks per drinking day did not differ significantly between groups. Quantile regression demonstrated a decrease in drinking frequency in the middle to upper ranges of the distribution of drinking days and heavy/binge drinking days that differed significantly between intervention and control conditions. At follow-up, the intervention group had significantly fewer episodes of unprotected vaginal sex. No intervention effects were observed for other outcomes.

conclusionsBI reduces frequency of alcohol use and unprotected vaginal sex among HIV-infected women. More intensive services may be needed to lower drinks per drinking day and enhance care for more severely affected drinkers.

Indexed as

Alcohol DrinkingCounselingAdultFemaleHIV InfectionsHumansMiddle AgedOdds RatioPatient ComplianceRisk FactorsUnsafe Sex

Identifiers

PMID25967270
PMCPMC4634011
OpenAlexW259468206

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.