ArticleNeuroepidemiology2015
Familial versus Sporadic Essential Tremor: What Patterns Can One Decipher in Age of Onset?
Article in Neuroepidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Epidemiology of Pediatric Essential Tremor in the United States: A Systematic Literature Review from 2010 to 2020.Tremor and other hyperkinetic movements (New York, N.Y.) · 2022Pooled it
- How Common is Essential Tremor? Update on the Worldwide Prevalence of Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2021Pooled it
- An Investigation of Heterogeneity in Cerebellar Cortical Pathology Across Essential Tremor Cases: A Cluster Analysis.Cerebellum (London, England) · 2026Article
- Single-cell expression QTL analyses of the human cerebellum reveal vulnerability of oligodendrocytes in essential tremor.Nature genetics · 2026Article
- Article
- Features of "ET plus" correlate with age and tremor duration: "ET plus" may be a disease stage rather than a subtype of essential tremor.Parkinsonism & related disorders · 2021Article
- Wearable Peripheral Electrical Stimulation Devices for the Reduction of Essential Tremor: A Review.IEEE access : practical innovations, open solutions · 2021Article
- Gene expression analysis of the cerebellar cortex in essential tremor.Neuroscience letters · 2020Article
- Genetic Testing Preferences of Individuals in Families with Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2018Article
- Cerebellar pathology in childhood-onset vs. adult-onset essential tremor.Neuroscience letters · 2017Article
- Cerebellar Pathology in Familial vs. Sporadic Essential Tremor.Cerebellum (London, England) · 2017Article
- Cerebellar Pathology in Early Onset and Late Onset Essential Tremor.Cerebellum (London, England) · 2017Article
- The Role of β-Carboline Alkaloids in the Pathogenesis of Essential Tremor.Cerebellum (London, England) · 2016Review
- Memory Similarities Between Essential Tremor and Parkinson's Disease: A Final Common Pathway?The Clinical neuropsychologist · 2015Article
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3 authors.
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Abstract
backgroundEssential tremor (ET) is a very prevalent neurological disease. Although familial and sporadic ET cases are assumed to have different age at onset distributions, no detailed study of this question has been carried out.
methodsUsing a carefully characterized sample of 376 ET cases (232 (61.7%) familial) enrolled in a clinical-epidemiological study, we contrasted the age of onset distributions in familial versus sporadic ET.
resultsFamilial ET had a lower age at onset distribution, regardless of the current age. The majority (71 (86.6%) of 82) of ET cases that appeared during childhood were familial rather than sporadic. Additionally, the onset of ET occurred after age 40 in a majority of cases (125 (53.9%) of 232 with familial ET and 118 (81.9%) of 144 with sporadic ET), and in approximately one-quarter to one-half of cases, after age 60.
conclusionsThe age of onset of ET differs between familial and sporadic ET and furthermore, is variable within each of these groups. The onset of ET during childhood is usually familial, and the small number of identified exceptions could be due to de novo mutations. Understanding the heterogeneity in onset age will provide insights into the nature of underlying etiological and patho-biological processes about which little is presently known.
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