ArticleClinical research in cardiology : official journal of the German Cardiac Society2015
Association between muscular strength and inflammatory markers among elderly persons with cardiac disease: results from the KORA-Age study.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Gender difference in the effects of interleukin-6 on grip strength - a systematic review and meta-analysis.BMC geriatrics · 2018Pooled it
- Is inflammation a missing link between relative handgrip strength with hyperlipidemia? Evidence from a large population-based study.Lipids in health and disease · 2024Article
- Dynapenia and Sarcopenia in Post-COVID-19 Syndrome Hospitalized Patients Are Associated with Severe Reduction in Pulmonary Function.Journal of clinical medicine · 2023Article
- Indoxyl sulfate mediates low handgrip strength and is predictive of high hospitalization rates in patients with end-stage renal disease.Frontiers in medicine · 2023Article
- The association between dietary inflammatory index, muscle strength, muscle endurance, and body composition in Iranian adults.Eating and weight disorders : EWD · 2022Article
- Handgrip strength and the risk of major depressive disorder: a two-sample Mendelian randomisation study.General psychiatry · 2022Article
- Blood and skeletal muscle ageing determined by epigenetic clocks and their associations with physical activity and functioning.Clinical epigenetics · 2021Article
- Physical Activity and Diet Shape the Immune System during Aging.Nutrients · 2020Review
- Article
- Association between muscular strength and depressive symptoms : A narrative review.Wiener klinische Wochenschrift · 2019Review
- Impact of handgrip strength on cardiovascular, cancer and all-cause mortality in the Korean longitudinal study of ageing.BMJ open · 2019Observational
- Associations of statin use with motor performance and myalgia may be modified by 25-hydroxyvitamin D: findings from a British birth cohort.Scientific reports · 2017Article
- Gender differences in the association between grip strength and mortality in older adults: results from the KORA-age study.BMC geriatrics · 2016Article
- Influence of exercise training on proangiogenic TIE-2 monocytes and circulating angiogenic cells in patients with peripheral arterial disease.Clinical research in cardiology : official journal of the German Cardiac Society · 2016Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Little is known about the association between muscle strength and inflammation in diseased individuals and particularly in cardiac patients. Thus, our purpose was to examine the association of muscular strength with the inflammatory status in older adults with and without cardiac disease. The cross-sectional analysis was based on 1079 adults aged 65-94 years, who participated in the KORA-Age study. Participants underwent an interview and extensive physical examinations including anthropometric measurements, registration of diseases and drug intake, determination of health-related behaviors, collection of blood samples for measurements of interleukin-6 and hs-CRP and muscle strength measurement using hand-grip dynamometry. Cardiac patients (n = 323) had higher levels of IL-6 and poorer muscle strength compared with older adults without cardiac disease. Among persons with cardiac diseases, muscle strength in the lower tertile compared to the upper tertile was significantly associated with increased odds of having elevated IL-6 levels (OR 3.53, 95 % CI 1.18-10.50, p = 0.024) after controlling for age, gender, body fat, alcohol intake, smoking status, diseases, medications and physical activity, whereas the association between muscle strength and hs-CRP remained borderline significant (OR 2.80, 95 % CI 0.85-9.24, p = 0.092). The same trends, with slightly lower odds ratios, were also observed in older adults without cardiac disease. Lower levels of muscular strength are associated with higher concentrations of IL-6 and hs-CRP in elderly individuals with and without cardiac disease suggesting a significant contribution of the muscular system in reducing low-grade inflammation that accompanies cardiac disease and aging.
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