ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2015
Cafeteria diet-fed mice is a pertinent model of obesity-induced organ damage: a potential role of inflammation.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Cardioprotective effect of spirulina on cafeteria diet-induced cardiac injury in silico and in vivo study.Journal of the science of food and agriculture · 2026Article
- An ultra-processed food-based cafeteria diet induces obesity, metabolic dysfunction, and tissue-specific gene dysregulation in C57BL/6 mice.Animal models and experimental medicine · 2026Article
- Experimental Models for Studying Cardiovascular Dysfunction in Metabolic Syndrome.Handbook of experimental pharmacology · 2026Review
- Wheat Flour Intake Promotes Weight Gain and Metabolic Changes in Mice.Molecular nutrition & food research · 2026Article
- Effects of Ultra-Processed Diets on Adiposity, Gut Barrier Integrity, Inflammation, and Microbiota in Male and Female Mice.Nutrients · 2025Article
- Myeloperoxidase, extracellular DNA and neutrophil extracellular trap formation in the animal models of metabolic dysfunction-associated steatotic liver disease.World journal of gastroenterology · 2025Article
- Protective and Therapeutic Effects of Orlistat in Combination withMedicina (Kaunas, Lithuania) · 2025Article
- Cafeteria diet compromises natural adaptations of islet cell transdifferentiation and turnover in pregnancy.Diabetic medicine : a journal of the British Diabetic Association · 2025Article
- Metabolic and ultrastructural renal changes in adult Wistar rats fed by a cafeteria diet.Acta cirurgica brasileira · 2024Article
- Relative Recovery of Non-Alcoholic Fatty Liver Disease (NAFLD) in Diet-Induced Obese Rats.Nutrients · 2023Article
- Rhythm and ROS: Hepatic Chronotherapeutic Features of Grape Seed Proanthocyanidin Extract Treatment in Cafeteria Diet-Fed Rats.Antioxidants (Basel, Switzerland) · 2023Article
- The ambiguous role of obesity in oncology by promoting cancer but boosting antitumor immunotherapy.Journal of biomedical science · 2022Review
- Kinin B1 receptor deficiency protects mice fed by cafeteria diet from abnormal glucose homeostasis.PloS one · 2022Article
- Mothers' cafeteria diet induced sex-specific changes in fat content, metabolic profiles, and inflammation outcomes in rat offspring.Scientific reports · 2021Article
- Influenza in High-Risk Hosts-Lessons Learned from Animal Models.Cold Spring Harbor perspectives in medicine · 2020Review
- Effects of a Fat-Rich Diet on the Spontaneous Release of Acetylcholine in the Neuromuscular Junction of Mice.Nutrients · 2020Article
- Ghrelin-induced multi-organ damage in mice fed obesogenic diet.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2020Article
- Impact of Lifestyles (Diet and Exercise) on Vascular Health: Oxidative Stress and Endothelial Function.Oxidative medicine and cellular longevity · 2020Review
- Effects of different diets used in diet-induced obesity models on insulin resistance and vascular dysfunction in C57BL/6 mice.Scientific reports · 2019Article
- Oxidative Imbalance and Kidney Damage: New Study Perspectives from Animal Models to Hospitalized Patients.Antioxidants (Basel, Switzerland) · 2019Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study is aimed at evaluating the effects of a cafeteria diet (obesity) mouse model on early multi-organ functional, structural, endocrine and biochemical alterations. MATERIALS AND
methodsMulti-organ damage is assessed using clinical, biochemical, pathological, and inflammatory parameters in 30 mice fed one of the three diets for 15 weeks: standard chow diet (SC), high fat (HF), or "Cafeteria diet" (CAF) (standard SC and a choice of highly palatable human cafeteria foods: chocolate, biscuits, and peanut butter).
resultsCAF diet was associated with an increase in body weight, energy intake, and serum cholesterol levels compared to the other diets, as well as higher insulin levels and lower glucose tolerance. Additionally, consumption of the CAF diet was associated with significantly higher weight gain, abdominal fat, and serum IL-6 levels, as well as more damage in the heart (coronary perivascular fibrosis and steatosis), kidney (chronic interstitial inflammation and glomerular sclerosis), and liver (liver weight, portal fibrosis, apoptosis, and steatosis) compared to the HF diet.
conclusionFunctional and structural damage in CAF were higher than HF of similar macronutrient composition. This study provides a novel dietary model in mice that mimics multi-organ physiologic alterations in humans secondary to obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.