Evidence map›Paper›PMID 25966908›Full record

ReviewCurrent opinion in genetics & development2015

Balancing up and downregulation of the C. elegans X chromosomes.

Alyssa C Lau, Györgyi Csankovszki

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in genetics & development, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
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  13. Condensin action and compaction.Current genetics · 2019
    Review
  14. Article
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  19. StableProceedings of the National Academy of Sciences of the United States of America · 2016
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Alyssa C LauDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, USA.
Györgyi CsankovszkiDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, USA. Electronic address: gyorgyi@umich.edu.

Funding

The Dosage Compensation Machinery of C. ElegansR01GM079533 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CSANKOVSZKI, GYORGYI · 2007 to 2015
$2.5M
NIGMS NIH HHS GM079533NIGMS NIH HHS R01 GM079533
6 · The paper itself

Abstract

In Caenorhabditis elegans, males have one X chromosome and hermaphrodites have two. Emerging evidence indicates that the male X is transcriptionally more active than autosomes to balance the single X to two sets of autosomes. Because upregulation is not limited to males, hermaphrodites need to strike back and downregulate expression from the two X chromosomes to balance gene expression in their genome. Hermaphrodite-specific downregulation involves binding of the dosage compensation complex to both Xs. Advances in recent years revealed that the action of the dosage compensation complex results in compaction of the X chromosomes, changes in the distribution of histone modifications, and ultimately limiting RNA Polymerase II loading to achieve chromosome-wide gene repression.

Indexed as

X ChromosomeAnimalsCaenorhabditis elegansDNA, HelminthDosage Compensation, GeneticDown-RegulationUp-RegulationDNA, Helminth

Identifiers

PMID25966908
PMCPMC4470837

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.