ReviewJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2015
Brown adipose tissue: physiological function and evolutionary significance.
Review in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
131 citing papers in PubMed, 2 syntheses or guidelines pooled it, 285 citations in OpenAlex.
- Gut Microbial Community and Host Thermoregulation in Small Mammals.Frontiers in physiology · 2022Pooled it
- Association between circulating neuregulin4 levels and diabetes mellitus: A meta-analysis of observational studies.PloS one · 2019Pooled it
- Abdominal visceral to subcutaneous fat distribution in dogs: computed tomography accuracy and factors associated with distribution.BMC veterinary research · 2026Article
- SEL1L-HRD1 ERAD-autophagy interplay maintains mitochondrial homeostasis in brown adipocytes.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Spatial Transcriptomics of Adipose Tissue: Technologies, Applications, and Challenges.Journal of obesity & metabolic syndrome · 2025Review
- Natural Mutation in Naked Mole-Rat UCP1 Refutes Importance of the Histidine Pair Motif for Proton Conductance and Thermogenesis.Acta physiologica (Oxford, England) · 2025Article
- Caffeine: a potential mechanism for anti-obesity.Purinergic signalling · 2025Review
- Aging-Related Obesity: Unveiling Mitochondrial and Metabolic Dysfunction.Current nutrition reports · 2025Review
- Low irisin levels are associated with increased body weight and an adverse metabolic profile.Archives of endocrinology and metabolism · 2025Article
- Individual Mechanical Energy Expenditure Regimens Vary Seasonally with Weather, Sex, Age and Body Condition in a Generalist Carnivore Population: Support for Inter-Individual Tactical Diversity.Animals : an open access journal from MDPI · 2025Article
- Article
- Adipose Tissue in Chagas Disease: A Neglected Component of Pathogenesis.Pathogens (Basel, Switzerland) · 2025Review
- Blocking the SIRPα-CD47 axis promotes macrophage phagocytosis of exosomes derived from visceral adipose tissue and improves inflammation and metabolism in mice.Journal of biomedical science · 2025Article
- Evolution ofInternational journal of molecular sciences · 2025Article
- Single-nucleus transcriptomes reveal the underlying mechanisms of dynamic whitening in thermogenic adipose tissue in goats.Journal of animal science and biotechnology · 2025Article
- SGLT2 inhibitors as metabolic modulators: beyond glycemic control in type 2 diabetes.Frontiers in endocrinology · 2025Review
- NFE2L1 as a central regulator of proteostasis in neurodegenerative diseases: interplay with autophagy, ferroptosis, and the proteasome.Frontiers in molecular neuroscience · 2025Review
- Hypoxia Regulates Brown Adipocyte Differentiation and Stimulates miR-210 by HIF-1α.International journal of molecular sciences · 2024Article
- Mitochondrial membrane lipids in the regulation of bioenergetic flux.Cell metabolism · 2024Review
- Perivascular Adipose Tissue and Uterine Artery Adaptations to Pregnancy.Microcirculation (New York, N.Y. : 1994) · 2024Review
71 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In modern eutherian (placental) mammals, brown adipose tissue (BAT) evolved as a specialized thermogenic organ that is responsible for adaptive non-shivering thermogenesis (NST). For NST, energy metabolism of BAT mitochondria is increased by activation of uncoupling protein 1 (UCP1), which dissipates the proton motive force as heat. Despite the presence of UCP1 orthologues prior to the divergence of teleost fish and mammalian lineages, UCP1's significance for thermogenic adipose tissue emerged at later evolutionary stages. Recent studies on the presence of BAT in metatherians (marsupials) and eutherians of the afrotherian clade provide novel insights into the evolution of adaptive NST in mammals. In particular studies on the 'protoendothermic' lesser hedgehog tenrec (Afrotheria) suggest an evolutionary scenario linking BAT to the onset of eutherian endothermy. Here, we review the physiological function and distribution of BAT in an evolutionary context by focusing on the latest research on phylogenetically distinct species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.