ArticleOncotarget2015
Perioperative cerebral ischemia promote infiltrative recurrence in glioblastoma.
Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Spatial patterns of progression in reported glioblastoma cohorts after upfront chemoradiation and salvage therapy: a systematic review and meta-analysis.Journal of neuro-oncology · 2026Pooled it
- Impact on survival of glioblastoma patients in relation to the imaging of the peri-surgical area: a multi-parametric diffusion MRI, perfusion MRI, and [11C]MET PET study.The British journal of radiology · 2026Article
- Single Institution Retrospective Study to Determine Time to First True Progression in MGMT-Methylated Glioblastoma Patients Who Received Standard of Care.Journal of clinical medicine · 2026Article
- Postoperative ischemia and neurological deficits after glioma resection: A systematic review and meta-analysis.Neuro-oncology practice · 2026Review
- Surgical decision making in the era of supramarginal glioma resections: a current perspective and narrative review.CNS oncology · 2025Review
- Survival implications of postoperative restricted diffusion in high-grade glioma and limitations of intraoperative MRI detection.Journal of neuro-oncology · 2024Article
- Risk Factors of Distant Recurrence and Dissemination ofCancers · 2024Review
- Evolution of phenotypic plasticity leads to tumor heterogeneity with implications for therapy.PLoS computational biology · 2024Article
- Diagnosis and management of complications from the treatment of primary central nervous system tumors in adults.Neuro-oncology · 2023Article
- MGMT Methylated High Grade Glioma with Distant Recurrence and Stable Original Tumor Site: Case Series.Annals of hematology & oncology · 2023Article
- Brain infarction following meningioma surgery-incidence, risk factors, and impact on function, seizure risk, and patient-reported quality of life.Neurosurgical review · 2022Article
- Optimal timing of radiotherapy following brain metastases surgery.Neuro-oncology practice · 2022Article
- Article
- Metabolic Parameters Influence Brain Infarction and Outcome after Resection of Brain Metastases.Cancers · 2020Article
- Delay in diagnosing patients with right-sided glioblastoma induced by hemispheric-specific clinical presentation.Journal of neuro-oncology · 2020Article
- The Impact of Perioperative Arterial Infarct on Recurrence, Functional Outcomes, and Survival in Glioblastoma Patients.Frontiers in oncology · 2020Article
- Gene Suppression of Transketolase-Like Protein 1 (TKTL1) Sensitizes Glioma Cells to Hypoxia and Ionizing Radiation.International journal of molecular sciences · 2018Article
- Retrospective Analysis of Radiological Recurrence Patterns in Glioblastoma, Their Prognostic Value And Association to Postoperative Infarct Volume.Scientific reports · 2018Article
- Safe Brain Tumor Resection Does not Depend on Surgery Alone - Role of Hemodynamics.Scientific reports · 2017Article
- Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypoxia is a key driver for infiltrative growth in experimental gliomas. It has remained elusive whether tumor hypoxia in glioblastoma patients contributes to distant or diffuse recurrences. We therefore investigated the influence of perioperative cerebral ischemia on patterns of progression in glioblastoma patients.
methodsWe retrospectively screened MRI scans of 245 patients with newly diagnosed glioblastoma undergoing resection for perioperative ischemia near the resection cavity. 46 showed relevant ischemia nearby the resection cavity. A control cohort without perioperative ischemia was generated by a 1:1 matching using an algorithm based on gender, age and adjuvant treatment. Both cohorts were analyzed for patterns of progression by a blinded neuroradiologist.
resultsThe percentage of diffuse or distant recurrences at first relapse was significantly higher in the cohort with perioperative ischemia (61.1%) compared to the control cohort (19.4%). The results of the control cohort matched well with historical data. The change in patterns of progression was not associated with a difference in survival.
conclusionsThis study reveals an unrecognized association of perioperative cerebral ischemia with distant or diffuse recurrence in glioblastoma. It is the first clinical study supporting the concept that hypoxia is a key driver of infiltrative tumor growth in glioblastoma patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.