ArticleThe British journal of dermatology2015
Classification of neurological abnormalities in children with congenital melanocytic naevus syndrome identifies magnetic resonance imaging as the best predictor of clinical outcome.
Article in The British journal of dermatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 111 citations in OpenAlex.
- Neurological signs, symptoms and MRI abnormalities in patients with congenital melanocytic naevi and evaluation of routine MRI-screening: systematic review and meta-analysis.Orphanet journal of rare diseases · 2022Pooled it
- Mitotic Proliferative Nodule Within a Giant Congenital Nevus: One Case Report and Updated Review.Dermatopathology (Basel, Switzerland) · 2026Review
- Efficacy of azacitidine and trametinib against leptomeningeal melanosis associated with congenital melanocytic nevus syndrome.Molecular and cellular pediatrics · 2026Review
- Clinical Features and Risks of Congenital Melanocytic Naevi: A Retrospective Analysis of Patients at the Queensland Children's Hospital.The Australasian journal of dermatology · 2025Article
- Congenital melanocytic neoplasms: clinical, histopathological and recent molecular developments.Virchows Archiv : an international journal of pathology · 2025Review
- Central Nervous System Involvement and Neuroradiological Imaging Insights of Neurocutaneous Melanocytosis in Congenital Melanocytic Nevi.Diagnostics (Basel, Switzerland) · 2024Article
- Neurocutaneous Melanosis with Meningeal Melanocytosis: A Rare Case of Intracranial Hypertension and Cutaneous Manifestations.Life (Basel, Switzerland) · 2024Article
- Updates in the Management of Congenital Melanocytic Nevi.Children (Basel, Switzerland) · 2024Review
- Case Report: Prenatal ultrasound presentation of congenital melanocytic nevus syndrome.Frontiers in pediatrics · 2024Article
- Incidence of neurocutaneous melanosis in Japanese pediatric patients with congenital melanocytic nevi.Scientific reports · 2023Article
- Congenital melanocytic naevus syndrome and Dandy-Walker malformation - a mistaken association: case report and literature review.Neuroradiology · 2023Review
- Neurocutaneous melanocytosis-associated malignant melanoma presenting with peritoneal seeding.Pediatric dermatology · 2021Article
- SKAP2-BRAF fusion and response to an MEK inhibitor in a patient with metastatic melanoma resistant to immunotherapy.BMJ case reports · 2021Article
- Management of Congenital Melanocytic Naevi in Children: A French National Survey Using Clinical Vignettes.Acta dermato-venereologica · 2020Article
- Neurocutaneous melanocytosis (melanosis).Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- Final congenital melanocytic naevi colour is determined by normal skin colour and unaltered by superficial removal techniques: a longitudinal study.The British journal of dermatology · 2020Article
- Does the gene matter? Genotype-phenotype and genotype-outcome associations in congenital melanocytic naevi.The British journal of dermatology · 2020Article
- Imaging of pediatric cutaneous melanoma.Pediatric radiology · 2019Review
- Giant Congenital Melanocytic Nevus Accompanied by an Intracranial Arachnoid Cyst.Dermatology practical & conceptual · 2019Article
- Posterior quadrantic dysplasia with localized hemimegalencephaly in a patient with giant congenital melanocytic nevus: First case report.The neuroradiology journal · 2019Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe spectrum of central nervous system (CNS) abnormalities described in association with congenital melanocytic naevi (CMN) includes congenital, acquired, melanotic and nonmelanotic pathology. Historically, symptomatic CNS abnormalities were considered to carry a poor prognosis, although studies from large centres have suggested a much wider variation in outcome.
objectivesTo establish whether routine MRI of the CNS is a clinically relevant investigation in children with multiple CMN (more than one at birth), and to subclassify radiological abnormalities.
methodsOf 376 patients seen between 1991 and 2013, 289 fulfilled our criterion for a single screening CNS MRI, which since 2008 has been more than one CMN at birth, independent of size and site of the largest naevus. Cutaneous phenotyping and radiological variables were combined in a multiple regression model of long-term outcome measures (abnormal neurodevelopment, seizures, requirement for neurosurgery).
resultsTwenty-one per cent of children with multiple CMN had an abnormal MRI. Abnormal MRI was the most significant predictor of all outcome measures. Abnormalities were subclassified into group 1 'intraparenchymal melanosis alone' (n = 28) and group 2 'all other pathology' (n = 18). Group 1 was not associated with malignancy or death during the study period, even when symptomatic with seizures or developmental delay, whereas group 2 showed a much more complex picture, requiring individual assessment.
conclusionsFor screening for congenital neurological lesions a single MRI in multiple CMN is a clinically relevant strategy. Any child with a stepwise change in neurological/developmental symptoms or signs should have an MRI with contrast of the brain and spine to look for new CNS melanoma.
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