Observational studyClinical cardiology2015
Beneficial Effects of Positive Airway Pressure Therapy for Sleep-Disordered Breathing in Heart Failure Patients With Preserved Left Ventricular Ejection Fraction.
Observational study in Clinical cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Positive airway pressure therapy for the treatment of central sleep apnoea associated with heart failure.The Cochrane database of systematic reviews · 2019Pooled it
- Cheyne-Stokes respiration detected via CPAP devices as a digital biomarker for heart failure in obstructive sleep apnoea: systematic review.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Heart Failure with Preserved Ejection Fraction: How to Deal with This Chameleon.Journal of clinical medicine · 2024Review
- Continuous positive airway pressure treatment in sleep apnea: patient compliance and impact on the right heart.Sleep and biological rhythms · 2022Article
- Cheyne-Stokes Breathing as a Predictive Indicator of Heart Failure in Patients With Obstructive Sleep Apnea; A Retrospective Case Control Study Using Continuous Positive Airway Pressure Remote Monitoring Data.Frontiers in cardiovascular medicine · 2022Article
- Feasibility of Transcatheter Caval Valve Implantation to ImproveFrontiers in cardiovascular medicine · 2021Article
- Hypertension as a Road to Treatment of Heart Failure with Preserved Ejection Fraction.Current hypertension reports · 2020Review
- Prognostic impacts of changes in left ventricular ejection fraction in heart failure patients with preserved left ventricular ejection fraction.Open heart · 2020Observational
- Sleep Disordered Breathing and Cardiovascular Diseases.Journal of atherosclerosis and thrombosis · 2019Review
- Association between sleep-disordered breathing and arterial stiffness in heart failure patients with reduced or preserved ejection fraction.ESC heart failure · 2018Article
- Heart failure and sleep disordered breathing.Fukushima journal of medical science · 2017Review
- Current Perspectives on Systemic Hypertension in Heart Failure with Preserved Ejection Fraction.Current hypertension reports · 2017Review
- Sleep disordered breathing in older adults with heart failure with preserved ejection fraction.Geriatric nursing (New York, N.Y.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRight-heart dysfunction is associated with poor prognosis in heart failure with preserved left ventricular ejection fraction (HFpEF). It remains unclear whether sleep-disordered breathing (SDB) treatment using positive airway pressure (PAP) improves right-heart and pulmonary function and exercise capacity and reduces mortality rates of HFpEF patients. HYPOTHESIS: PAP may improve right-heart and pulmonary function, exercise capacity and prognosis in HFpEF patients with SDB.
methodsOne hundred nine consecutive patients with HFpEF (left ventricular ejection fraction >50%) and moderate to severe SDB (apnea-hypopnea index ≥15/h) treated with medications were divided into 2 groups: 31 patients with PAP (PAP group) and 78 patients without PAP (non-PAP group). Right ventricular fractional area change (RV-FAC), tricuspid valve regurgitation pressure gradient (TR-PG), tricuspid valve E/E', forced expiratory volume in 1 second/forced vital capacity (FEV1 /FVC), percentage of vital capacity, and peak VO2 were determined before and 6 months later, and all-cause mortality was followed up for 916 days.
resultsAll parameters improved in the PAP group (RV-FAC, 36.0% -46.5%; TR-PG, 31.1 mm Hg-22.4 mm Hg; tricuspid valve E/E', 7.8-5.1; FEV1 /FVC, 83.9%-89.8%; percentage of vital capacity, 83.5%-89.9%; and peak VO2 , 16.6 mL/kg/min-19.6 mL/kg/min; P <0.05, respectively) but not in the non-PAP group. Importantly, all-cause mortality was significantly lower in the PAP group than in the non-PAP group (0% vs 12.8%; log-rank P = 0.014).
conclusionsPositive airway pressure improves right-heart and pulmonary function and exercise capacity and may reduce all-cause mortality in patients with HFpEF and SDB.
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