ArticleScientific reports2015
Skin rejuvenation with non-invasive pulsed electric fields.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 60 citations in OpenAlex.
- Efficacy, Safety, and Tolerability of a Wearable Electrotrichogenic Device in Men with Androgenetic Alopecia: A Randomized, Double-Blind, Sham-Controlled Trial.Dermatology and therapy · 2026Article
- Kv1.3 Ion Channels Mediate Electrical Stimulation-Induced Collagen Expression in Human Dermal Fibroblasts.Cosmetics · 2025Article
- Novel Electrotrichogenic Device Promotes Hair Growth in Men With Androgenetic Alopecia: A Pilot Study.Journal of cosmetic dermatology · 2025Article
- Noninvasive Self-Powered Iontophoresis Mask Based on a Water-Driven Fiber Battery.Research (Washington, D.C.) · 2025Article
- Pulsed electrical stimulation and amino acid derivatives promote collagen gene expression in human dermal fibroblasts.Cytotechnology · 2024Article
- Investigation of osmotic shock effect on pulsed electric field treated S. cerevisiae yeast cells.Scientific reports · 2023Article
- The quantitative investigation of spark plasma on skin parameters with skin elasticity, thickness, density, and biometric characteristics.Scientific reports · 2023Article
- VEGF Expression, Cellular Infiltration, and Intratumoral Collagen Levels after Electroporation-Based Treatment of Dogs with Cutaneous Squamous Cell Carcinoma.Life (Basel, Switzerland) · 2021Article
- In vivo study of the effects of a portable cold plasma device and vitamin C for skin rejuvenation.Scientific reports · 2021Article
- High-Voltage, Pulsed Electric Fields EliminateAdvances in wound care · 2021Article
- Article
- Combinatorial effect of radium-223 and irreversible electroporation on prostate cancer bone metastasis in mice.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2021Article
- Differential Cell Death and Regrowth of Dermal Fibroblasts and Keratinocytes After Application of Pulsed Electric Fields.Bioelectricity · 2020Article
- Article
- Selective Inactivation ofAdvances in wound care · 2019Article
- Ciprofloxacin-lidocaine-based hydrogel: development, characterization, and in vivo evaluation in a second-degree burn model.Drug delivery and translational research · 2018Article
- Skin regeneration with all accessory organs following ablation with irreversible electroporation.Journal of tissue engineering and regenerative medicine · 2018Article
- [Mechanism of lipolytic and smooth effects of D980-nm laser treatment on skin tissue in rats].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2017Article
- Preventing Scars after Injury with Partial Irreversible Electroporation.The Journal of investigative dermatology · 2016Article
- Electrotransfer parameters as a tool for controlled and targeted gene expression in skin.Molecular therapy. Nucleic acids · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
Degenerative skin diseases affect one third of individuals over the age of sixty. Current therapies use various physical and chemical methods to rejuvenate skin; but since the therapies affect many tissue components including cells and extracellular matrix, they may also induce significant side effects, such as scarring. Here we report on a new, non-invasive, non-thermal technique to rejuvenate skin with pulsed electric fields. The fields destroy cells while simultaneously completely preserving the extracellular matrix architecture and releasing multiple growth factors locally that induce new cells and tissue growth. We have identified the specific pulsed electric field parameters in rats that lead to prominent proliferation of the epidermis, formation of microvasculature, and secretion of new collagen at treated areas without scarring. Our results suggest that pulsed electric fields can improve skin function and thus can potentially serve as a novel non-invasive skin therapy for multiple degenerative skin diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.