ArticleCancer cell2015
Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups.
2 registry-linked trialsOpen access · bronzeAbstract read
In one paragraph
Article in Cancer cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 641 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
641citing papers in PubMed, 4 pooled it
50.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Ependymomics: Multiomic Approach to Radioresistance of Ependymomas in Children and Adolescents
PaCIFiC-CUP：Pan-Cancer Integrated Fingerprinting Classifier for Identifying the Origin of Cancer of Unknown Primary: A Multi-Center Prospective Cohort Study
Who cites it
641 citing papers in PubMed, 4 syntheses or guidelines pooled it, 1,209 citations in OpenAlex.
- Impact of molecular subtypes on postoperative hydrocephalus following resection of posterior fossa medulloblastoma and ependymoma in children: A systematic review and meta-analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Pooled it
- EANS-EANO guidelines on the extent of resection in gliomas.Neuro-oncology · 2026Guideline
- Clinical characteristics and prognostic factors of primary spinal subependymoma: a single-center cohort study and systematic review.Journal of neuro-oncology · 2025Pooled it
- Demystifying the potential of lipid-based nanocarriers in targeting brain malignancies.Naunyn-Schmiedeberg's archives of pharmacology · 2024Pooled it
- AOSNP-ADAPTR resource level-based recommendations on practical diagnostic strategies for ependymomas.Brain pathology (Zurich, Switzerland) · 2026Article
- East Asian multi-centre study on clinical long-term outcomes of postoperative proton beam therapy for localised paediatric intracranial ependymoma.Clinical and translational radiation oncology · 2026Article
- Chromosome 6q mediated loss of LATS1 tumour suppression as a targetable mechanism of ultra-high-risk posterior fossa A ependymoma.Acta neuropathologica · 2026Article
- Supratentorial ependymoma: a comprehensive review of molecular classification, management strategies, and clinical outcomes (Part II of pediatric ependymomas across compartments).Journal of neuro-oncology · 2026Review
- Spinal ependymoma: a comprehensive review of molecular classification, management guidelines, and clinical outcomes with a focus on the pediatric population (Part III of ependymomas across compartments).Journal of neuro-oncology · 2026Review
- Gliomas with pleomorphic and pseudopapillary features (GPAP) are circumscribed tumors with targetable mutations, prolonged survival, and frequent tumor predisposition.Brain pathology (Zurich, Switzerland) · 2026Article
- A patient-derived organoid platform for predominantly posterior fossa adult ependymoma: histopathologic preservation, culture-associated transcriptomic remodeling, and in vivo tumorigenicity.Journal of neuro-oncology · 2026Article
- Posterior fossa ependymoma: a comprehensive review of molecular classification, management guidelines, and clinical outcomes (Part I of ependymomas across compartments).Journal of neuro-oncology · 2026Review
- "Updates on diagnostic and prognostic molecular biomarkers of CNS tumors".Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Review
- Long-term outcomes after adjuvant radiotherapy in adult spinal ependymomas: a multicenter study by the trod Neuro-Oncology research group (07 - 005).Journal of neuro-oncology · 2026Article
- Bridging pediatric and adult neuro-oncology: Insights into adolescents and young adults (AYA) central nervous system tumors.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Review
- CXorf67 in malignancies: Deciphering epigenetic landscapes and clinical implications for precision oncology.Genes & diseases · 2026Review
- Imaging diagnosis of cystic intraparenchymal brain neoplasms.Japanese journal of radiology · 2026Review
- Pediatric ependymoma in the molecular era: real-world experience with diagnostic correlation and long-term clinical outcomes.Journal of neuro-oncology · 2026Article
- Comprehensive metabolic characterization of pediatric ependymomas.Life metabolism · 2026Article
- Challenging anatomical paradigms: unexpected supratentorial localization of posterior fossa B ependymomas identified by DNA methylation.Acta neuropathologica communications · 2026Article
581 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
56 authors at 20 institutions in 9 countries.
Kristian W PajtlerDivision of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Department of Pediatric Oncology and Hematology, University Children's Hospital Essen, 45147 Essen, Germany.
Hendrik WittDivision of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Department of Pediatric Oncology, Hematology and Immunology, University Hospital, 69120 Heidelberg, Germany; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.
Martin SillDivision of Biostatistics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
David T W JonesDivision of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Volker HovestadtDivision of Molecular Genetics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Fabian KratochwilDivision of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Khalida WaniDepartment of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Ruth TatevossianDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Chandanamali PunchihewaDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Pascal JohannDivision of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Jüri ReimandThe Donnelly Center, University of Toronto, Toronto, ON M5S 3E1, Canada.
Hans-Jörg WarnatzDepartment of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.
Marina RyzhovaDepartment of Neuropathology, NN Burdenko Neurosurgical Institute, 125047 Moscow, Russia.
Steve MackDivision of Neurosurgery, Arthur & Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
Vijay RamaswamyDivision of Neurosurgery, Arthur & Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
David CapperDepartment of Neuropathology, University of Heidelberg, 69120 Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Leonille SchweizerDepartment of Neuropathology, University of Heidelberg, 69120 Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Laura SieberDivision of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Andrea WittmannDivision of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Zhiqin HuangDivision of Molecular Genetics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Peter van SluisDepartment of Oncogenomics, Academic Medical Center, 1105AZ Amsterdam, the Netherlands.
Richard VolckmannDepartment of Oncogenomics, Academic Medical Center, 1105AZ Amsterdam, the Netherlands.
Jan KosterDepartment of Oncogenomics, Academic Medical Center, 1105AZ Amsterdam, the Netherlands.
Rogier VersteegDepartment of Oncogenomics, Academic Medical Center, 1105AZ Amsterdam, the Netherlands.
Daniel FultsUniversity of Utah, Salt Lake City, UT 84132, USA.
Helen ToledanoPediatric Hematology Oncology, Schneider Children's Medical Center of Israel, 49202 Petah Tikva, Israel.
Smadar AvigadDepartment of Molecular Oncology, Schneider Children's Medical Center of Israel, Tel Aviv University, 49202 Tel Aviv, Israel.
Lindsey M HoffmanDepartment of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA.
Andrew M DonsonDepartment of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA.
Nicholas ForemanDepartment of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA.
Ekkehard HewerDepartment of Pathology, University of Bern, 3010 Bern, Switzerland.
Karel ZitterbartDepartment of Pediatric Oncology, Faculty of Medicine, University Hospital Brno and Masaryk University, 61300 Brno, Czech Republic; Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, 65653 Brno, Czech Republic.
Mark GilbertDivision of Cancer Medicine, Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Terri S ArmstrongDivision of Cancer Medicine, Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Family Health, University of Texas Health Science Center-SON, Houston, TX 77030, USA.
Nalin GuptaDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Jeffrey C AllenDepartments of Pediatrics and Neurology, NYU Langone Medical Center, New York, NY 10016, USA.
Matthias A KarajannisDivision of Pediatric Hematology and Oncology, Departments of Pediatrics and Otolaryngology, NYU Langone Medical Center, New York, NY 10016, USA.
David ZagzagDepartment of Pathology, NYU Langone Medical Center, New York, NY 10016, USA.
Martin HasselblattInstitute for Neuropathology, University Hospital Münster, 48149 Münster, Germany.
Andreas E KulozikDepartment of Pediatric Oncology, Hematology and Immunology, University Hospital, 69120 Heidelberg, Germany.
Olaf WittDepartment of Pediatric Oncology, Hematology and Immunology, University Hospital, 69120 Heidelberg, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
V Peter CollinsDepartment of Pathology, University of Cambridge, Cambridge CB2 1TN, UK.
Katja von HoffDepartment of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Stefan RutkowskiDepartment of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Torsten PietschDepartment of Neuropathology, University of Bonn, 53127 Bonn, Germany.
Gary BaderThe Donnelly Center, University of Toronto, Toronto, ON M5S 3E1, Canada.
Marie-Laure YaspoDepartment of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.
Andreas von DeimlingDepartment of Neuropathology, University of Heidelberg, 69120 Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Peter LichterGerman Cancer Consortium (DKTK), 69120 Heidelberg, Germany; Division of Molecular Genetics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Michael D TaylorDivision of Neurosurgery, Arthur & Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
Richard GilbertsonDepartment of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN 38105, USA.
David W EllisonDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Kenneth AldapeLaboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G 1L7, Canada.
Andrey KorshunovDepartment of Neuropathology, University of Heidelberg, 69120 Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Marcel KoolDivision of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. Electronic address: m.kool@dkfz.de.
Stefan M PfisterDivision of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Department of Pediatric Oncology, Hematology and Immunology, University Hospital, 69120 Heidelberg, Germany; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany. Electronic address: s.pfister@dkfz.de.
Heidelberg University · DEGerman Cancer Research Center · DEAmsterdam UMC Location University of Amsterdam · NLSt. Jude Children's Research Hospital · USNYU Langone Health · USThe University of Texas MD Anderson Cancer Center · USUniversity of Colorado Denver · USUniversity of Toronto · CAHospital for Sick Children · CAMax Planck Institute for Molecular Genetics · DESchneider Children's Medical Center · ILBurdenko Neurosurgery Institute · RUDeutschen Konsortium für Translationale Krebsforschung · DESickKids Foundation · CAUniversität Hamburg · DEUniversity Hospital Brno · CZUniversity Hospital Heidelberg · DEUniversity Hospital Münster · DEUniversity Medical Center Hamburg-Eppendorf · DEUniversity of Bern · CH
Funding
Project-005UL1TR001445 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BREDELLA, MIRIAM ANTOINETTE, HOCHMAN, JUDITH S · 2015 to 2025
$103.5MVaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ADRIANA HEGUY · 1985 to 2026
$83.1MInstitutional Clinical and Translational Science AwardUL1TR000038 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CRONSTEIN, BRUCE NEIL · 2012 to 2014
$16.8MKnowledge-based Gene Expression Analysis for Biomedical and Cancer ResearchR01CA121941 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MESIROV, JILL P. · 2006 to 2016
$5.1MAn Investigation of Radial Glia as the Source of Ependymoma Stem CellsR01CA129541 · NCI · UNIVERSITY OF CAMBRIDGE · PI GILBERTSON, RICHARD · 2007 to 2016
$3.0MNCATS NIH HHS UL 1 TR000038NCATS NIH HHS UL1 TR001445NCI NIH HHS P30 CA016087NCI NIH HHS P30CA016087NCI NIH HHS R01 CA121941NCI NIH HHS R01 CA129541
Abstract
Ependymal tumors across age groups are currently classified and graded solely by histopathology. It is, however, commonly accepted that this classification scheme has limited clinical utility based on its lack of reproducibility in predicting patients' outcome. We aimed at establishing a uniform molecular classification using DNA methylation profiling. Nine molecular subgroups were identified in a large cohort of 500 tumors, 3 in each anatomical compartment of the CNS, spine, posterior fossa, supratentorial. Two supratentorial subgroups are characterized by prototypic fusion genes involving RELA and YAP1, respectively. Regarding clinical associations, the molecular classification proposed herein outperforms the current histopathological classification and thus might serve as a basis for the next World Health Organization classification of CNS tumors.
Indexed as
Age FactorsAdaptor Proteins, Signal TransducingAdolescentAdultAgedCentral Nervous System NeoplasmsChildChild, PreschoolDNA MethylationEpendymomaFemaleGene DosageGene Expression ProfilingGene FusionHumansInfantAdaptor Proteins, Signal TransducingPhosphoproteinsTranscription FactorsYAP1 protein, humanYAP-Signaling Proteins
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Registered trials
NCT05151718ClinicalTrials.gov
NCT06140992ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.