ArticlePloS one2015
Obesity Does Not Influence Outcomes in Hepatocellular Carcinoma Patients following Curative Hepatectomy.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Impact of three-dimensional hepatic models on oncological outcomes and survival after hepatectomy: Prognostic factor analysis in a retrospective cohort.Annals of hepato-biliary-pancreatic surgery · 2026Article
- Prognostic value of CT-defined sarcopenic obesity in hepatocellular carcinoma patients undergoing transarterial chemoembolization.BMC gastroenterology · 2026Article
- Minimally invasive vs. open hepatectomy in patients with obesity and liver tumors: a systematic review and meta-analysis.Frontiers in surgery · 2026Review
- Metabolic dysfunction-associated fatty liver disease increases the risk of complications after radical resection in patients with hepatocellular carcinoma.World journal of surgical oncology · 2024Article
- RETRACTED: Effect of body mass index on the wound infection and complications in patients with liver cancer: A meta-analysis.International wound journal · 2024Article
- Obesity and its influence on liver dysfunction, morbidity and mortality after liver resection.Hepatobiliary surgery and nutrition · 2023Article
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- Obesity is not a risk factor for either mortality or complications after laparoscopic cholecystectomy for cholecystitis.Scientific reports · 2021Article
- Hepatocellular carcinoma in non-alcoholic fatty liver disease-a review of an emerging challenge facing clinicians.Hepatobiliary surgery and nutrition · 2021Review
- Influence of diabetes on short-term outcome after major hepatectomy: an underestimated risk?BMC surgery · 2020Article
- Is sarcopenic obesity superior to sarcopenia as a predicting indicator in patients with hepatocellular carcinoma following hepatic resection?Hepatobiliary surgery and nutrition · 2020Article
- Impact of overweightness and critical weight loss on overall survival in patients with hepatocellular carcinoma initially treated with chemoembolization.Gastroenterology report · 2020Article
- Impact of Body Composition on the Risk of Hepatocellular Carcinoma Recurrence After Liver Transplantation.Journal of clinical medicine · 2019Article
- Clinical conditions and treatment requirements for long-term survival among hepatitis B-related hepatocellular carcinoma initially treated with chemoembolization.Cancer medicine · 2019Article
- Observational
- Obesity as a surgical risk factor.Annals of gastroenterological surgery · 2018Review
- Article
- Effect of Body Mass Index on Intraoperative Complications During Hepatic Resection for Malignancy.ANZ journal of surgeryArticle
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundWhether obesity affects surgical outcomes in patients with hepatocellular carcinoma (HCC) is controversial. Here we retrospectively evaluated the impact of obesity on outcomes in HCC patients after curative hepatectomy.
methodsPatients with Child-Pugh A liver function who underwent curative hepatectomy between 2006 and 2010 were categorized as obese (BMI ≥25 kg/m2, n = 68) and non-obese (<25 kg/m2, n = 242). To reduce interference from baseline differences between the two groups, propensity score-matched analysis was performed in the ratio 1:2 using a caliper width of 0.1. Surgical outcomes were compared for 61 obese and 115 non-obese patients.
resultsObese patients had higher levels of albumin and aspartate aminotransferase, and more solitary tumors compared to the non-obese patients (all P<0.05). In the propensity-matched cohort, baseline characteristics did not differ between the two groups (all P>0.05). Obese and non-obese patients had comparable 30-day mortality (1.6% vs. 2.6%, P = 1.000), 90-day mortality (3.3% vs. 4.3%, P = 1.000), and incidence of postoperative complications (19.7% vs. 18.3%, P = 0.819). Overall survival at 1, 3, and 5 years was similar for obese patients (83.6%, 63.6%, 41.6%) as for non-obese patients (80.9%, 65.9%, 49.1%; P = 0.358). Disease-free survival at 1, 3, and 5 years was also similar for obese patients (71.5%, 36.3%, 24.3%) as for non-obese ones (60.2%, 43.7%, 27.7%; P = 0.969).
conclusionOur propensity score-matched analysis strengthens the case that obesity does not adversely affect surgical outcomes of HCC patients undergoing curative hepatectomy.
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