ArticleeLife2015
De novo synthesis of a sunscreen compound in vertebrates.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 92 citations in OpenAlex.
- Metabolic engineering ofSynthetic and systems biotechnology · 2026Article
- Vitamin D promotes endogenous sunscreen synthesis and ultraviolet protection in zebrafish.Science China. Life sciences · 2026Article
- Molecular Basis of α-Glycine C-H Activation by a Nonheme Fe(II)/2-Oxoglutarate Dioxygenase.Biochemistry · 2026Article
- Early ultraviolet exposure disrupts late dorsal fin skeletal development in zebrafish.Developmental dynamics : an official publication of the American Association of Anatomists · 2026Article
- Osmotic signaling governs sunscreen biosynthesis to safeguard desert cyanobacteria against desiccation.mLife · 2026Article
- Physiology and chemistry integration under UV-B across green algalFrontiers in microbiology · 2026Article
- A widespread metabolic gene cluster family in metazoans.Nature chemical biology · 2025Article
- Examples of Underexploited Marine Organisms in Cosmeceutical Applications.Marine drugs · 2025Review
- "Button-on-a-String" Mechanism in Water, the Ultrafast UV-to-Heat Conversion by Mycosporine-like Amino Acid Porphyra-334 of Natural Sunscreen Compound.ACS physical chemistry Au · 2025Article
- Applications of mycosporine-like amino acids beyond photoprotection.Applied and environmental microbiology · 2023Review
- Efficient production of mycosporine-like amino acids, natural sunscreens, in Yarrowia lipolytica.Biotechnology for biofuels and bioproducts · 2023Article
- Protective Effect of Mycosporine-like Amino Acids Isolated from an Antarctic Diatom on UVB-Induced Skin Damage.International journal of molecular sciences · 2023Article
- A Plastic Biosynthetic Pathway for the Production of Structurally Distinct Microbial Sunscreens.ACS chemical biology · 2023Article
- Gadusol is a maternally provided sunscreen that protects fish embryos from DNA damage.Current biology : CB · 2023Article
- Unraveling the Molecular Basis of Mycosporine Biosynthesis in Fungi.International journal of molecular sciences · 2023Article
- Recommendations for advancing test protocols examining the photo-induced toxicity of petroleum and polycyclic aromatic compounds.Aquatic toxicology (Amsterdam, Netherlands) · 2023Article
- Recent progress in unraveling the biosynthesis of natural sunscreens mycosporine-like amino acids.Journal of industrial microbiology & biotechnology · 2023Review
- Gadusol is a maternally provided sunscreen that protects fish embryos from DNA damage.bioRxiv : the preprint server for biology · 2023Article
- Article
- Investigating the Ultrafast Dynamics and Long-Term Photostability of an Isomer Pair, Usujirene and Palythene, from the Mycosporine-like Amino Acid Family.Molecules (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Ultraviolet-protective compounds, such as mycosporine-like amino acids (MAAs) and related gadusols produced by some bacteria, fungi, algae, and marine invertebrates, are critical for the survival of reef-building corals and other marine organisms exposed to high-solar irradiance. These compounds have also been found in marine fish, where their accumulation is thought to be of dietary or symbiont origin. In this study, we report the unexpected discovery that fish can synthesize gadusol de novo and that the analogous pathways are also present in amphibians, reptiles, and birds. Furthermore, we demonstrate that engineered yeast containing the fish genes can produce and secrete gadusol. The discovery of the gadusol pathway in vertebrates provides a platform for understanding its role in these animals, and the possibility of engineering yeast to efficiently produce a natural sunscreen and antioxidant presents an avenue for its large-scale production for possible use in pharmaceuticals and cosmetics.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.