ArticleWorld journal of virology2015
Molecular interactions between hepatitis B virus and delta virus.
Article in World journal of virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Prevalence and genotypes distribution of virus hepatitis B and hepatitis delta virus in chronic liver diseases in Kazakhstan.BMC infectious diseases · 2023Trial
- Review
- Article
- Impact of Hepatitis Delta Virus Infection on the Selection of Hepatitis B Surface Antigen Mutations.Genes · 2024Article
- Hepatitis B in Pediatric Population: Observational Retrospective Study in Romania.Life (Basel, Switzerland) · 2024Article
- Hepatitis B infection: Evaluation of demographics and treatment of chronic hepatitis B infection in Northern-western Tanzania.PloS one · 2024Article
- Modeling the Interplay between HDV and HBV in Chronic HDV/HBV Patients.Mathematics (Basel, Switzerland) · 2022Article
- Low prevalence of hepatitis delta infection in Cuban HBsAg carriers: Prospect for elimination.Frontiers in medicine · 2022Article
- Comprehensive Analysis of Hepatitis Delta Virus Assembly Determinants According to Genotypes: Lessons From a Study of 526 Hepatitis Delta Virus Clinical Strains.Frontiers in microbiology · 2021Article
- Advanced molecular surveillance approaches for characterization of blood borne hepatitis viruses.PloS one · 2020Article
- Impact of nucleic acid extraction platforms on hepatitis virus genome detection.Journal of virological methods · 2019Article
- Characterization of hepatitis B virus X gene quasispecies complexity in mono-infection and hepatitis delta virus superinfection.World journal of gastroenterology · 2019Article
- Hepatitis delta virus and hepatocellular carcinoma: an update.Epidemiology and infection · 2018Review
- HDV Can Constrain HBV Genetic Evolution in HBsAg: Implications for the Identification of Innovative Pharmacological Targets.Viruses · 2018Article
- Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection.Science translational medicine · 2018Article
- Characterization of hepatitis B and delta coinfection in Israel.BMC infectious diseases · 2018Article
- Prevalence and genotype distribution of hepatitis delta virus among chronic hepatitis B carriers in Central Vietnam.PloS one · 2017Article
- Hepatocarcinogenesis associated with hepatitis B, delta and C viruses.Current opinion in virology · 2016Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As a deficient virus due to the lack of envelope proteins, hepatitis D virus (HDV) causes chronic or fulminant "delta hepatitis" only in people with simultaneous hepatitis B virus (HBV) infection. HBV encodes three types of surface proteins known as small (S), medium (M) and large (L) envelope proteins. All three types of HBV surface antigens (HBsAgs) are present on HDV virions. The envelopment process of HDV occurs through interactions between the HDV ribonucleoprotein (RNP) complex and HBV HBsAgs. While HBsAg is the only protein required by HDV, the exact interaction sites between the S protein and pre-mature HDV are not well defined yet. In fact, these sites are distributed along the S protein with some hot spots for the envelopment process. Moreover, in most clinically studied samples, HDV infection is associated with a dramatically reduced HBV viral load, temporarily or permanently, while HBsAg resources are available for HDV packaging. Thus, beyond interacting with HBV envelope proteins, controlling mechanisms exist by which HDV inhibits HBV-DNA replication while allowing a selective transcription of HBV proteins. Here we discuss the molecular interaction sites between HBsAg and the HDV-RNP complex and address the proposed indirect mechanisms, which are employed by HBV and HDV to facilitate or inhibit each other's viral replication. Understanding molecular interactions between HBV and HDV may help to design novel therapeutic strategies for delta hepatitis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.