ArticleIranian Red Crescent medical journal2015
Efficacy and safety of aluminum chloride in controlling external hemorrhage: an animal model study.
Article in Iranian Red Crescent medical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Development of a 50% (w/v) aluminium chloride hexahydrate solution as haemostatic agent.European journal of hospital pharmacy : science and practice · 2025Article
- Review
- A Comparison of Ferric Subsulfate Solution, Silver Nitrate, and Aluminum Chloride for Pain Assessment, Time to Hemostasis, and Cosmesis in Acrochordon Snip Excision.The Journal of clinical and aesthetic dermatology · 2020Review
- Effect of Different Cleansing Protocols on Bond Strength of Composite Resin to Dentin Contaminated with Hemostatic Agent: An In Vitro Study.Frontiers in dentistry · 2020Article
- Evaluation of antioxidant and antimutagenic activities of aluminum chloride.European oral research · 2019Article
- The Effect of Hemostatic Agents on the Retention Strength of Zirconia Crowns Luted to Dentin Abutments.Materials (Basel, Switzerland) · 2019Article
- The Advantages and Disadvantages of Methods Used to Control Liver Bleeding: A Review.Trauma monthly · 2015Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite all the progress in surgical science, bleeding caused by traffic accidents is still one of the challenges surgeons face in saving patients' lives. Therefore, introducing an effective method to control external bleeding is an important research priority.
objectivesThis study aimed to compare the hemostatic effect of aluminum chloride versus simple suturing in controlling external bleeding. MATERIALS AND
methodsThis experimental study was conducted in Kashan, Iran. In this study, 60 male Wistar rats were randomly allocated into six groups. An incision, two centimeters (cm) long and half a cm deep, was made on each rat's shaved back skin and the hemostatic time was measured once using aluminum chloride with different concentrations (5%, 10%, 15%, 25%, and 50%) and then using the control method (controlling hemorrhage by simple suturing). The skin tissue was assessed for pathological changes.
resultsThe hemostatic time of aluminum chloride 50%, 25%, 15%, 10% and 5% were 8.20 ± 0.919, 14.10 ± 1.37, 21.20 ± 1.31, 30.80 ± 1.68 and 42.00 ± 4.19 seconds, respectively. Also, the mean hemostasis time in the control group (suture) was 84.00 ± 4.05 seconds. The hemostatic times of different concentrations of aluminum chloride were significantly less than that of the control group. There was a statistically significant difference between every two hemostatic time. The pathologic examination showed the highest frequency of low-grade inflammation based on the defined pathological grading.
conclusionsThe aluminum chloride method needs less time to control external hemorrhage compared to the control method (controlling external hemorrhage by simple suturing). Aluminum chloride is an effective agent in controlling external hemorrhage in an animal model.
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