ArticleJundishapur journal of microbiology2015
Biofilm Formation and β-Lactamase Production in Burn Isolates of Pseudomonas aeruginosa.
Article in Jundishapur journal of microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 47 citations in OpenAlex.
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- N-acyl homoserine lactone quorum-sensing inhibitor acts as an antibiotic adjuvant to increase the susceptibility of Pseudomonas aeruginosa against β-lactam antibiotics.Archives of microbiology · 2025Article
- Prevalence ofIranian journal of pathology · 2025Article
- Microbial risks in drinking water systems: persistence and public health implications of opportunistic premise plumbing pathogens.Frontiers in microbiology · 2025Article
- Biofilm formation and antimicrobial resistance pattern of uropathogenic E. coli ST131 isolated from children with malignant tumors.The Journal of antibiotics · 2024Article
- Genetic and environmental determinants of surface adaptations inMicrobiology (Reading, England) · 2023Article
- Prevalence of Quorum Sensing and Virulence Factor Genes AmongInfection and drug resistance · 2023Article
- Association of multidrug resistance behavior of clinical Pseudomonas aeruginosa to pigment coloration.European journal of medical research · 2022Article
- Association of quorum sensing and biofilm formation with Salmonella virulence: story beyond gathering and cross-talk.Archives of microbiology · 2021Review
- A phenotypic and molecular investigation of biofilm formation in clinical samples ofMolecular biology research communications · 2021Article
- In Vitro Antibacterial, Anti-Adhesive and Anti-Biofilm Activities ofAntibiotics (Basel, Switzerland) · 2021Article
- Study of quorum-sensingAccess microbiology · 2021Article
- Antibiotic Resistance, Biofilm Formation, and Presence of Genes Encoding Virulence Factors in Strains Isolated from the Pharmaceutical Production Environment.Pathogens (Basel, Switzerland) · 2021Article
- Multidrug ResistantFrontiers in microbiology · 2021Article
- Olive Leaf Extract Modulates Quorum Sensing Genes and Biofilm Formation in Multi-Drug ResistantAntibiotics (Basel, Switzerland) · 2020Article
- Association of biofilm formation with multi drug resistance in clinical isolates ofEXCLI journal · 2020Article
- Putative Bifunctional Chorismate Mutase/Prephenate Dehydratase Contributes to the Virulence ofFrontiers in plant science · 2020Article
- Study of biofilm formation and antibiotic resistance pattern of gram-negative Bacilli among the clinical isolates at BPKIHS, Dharan.BMC research notes · 2019Article
- Virulence Factors Of Carbapenem-ResistantInfection and drug resistance · 2019Article
- Pse-T2, an Antimicrobial Peptide with High-Level, Broad-Spectrum Antimicrobial Potency and Skin Biocompatibility against Multidrug-Resistant Pseudomonas aeruginosa Infection.Antimicrobial agents and chemotherapy · 2018Article
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundPseudomonas aeruginosa is an important nosocomial pathogen characterized by its innate resistance to multiple antimicrobial agents. Plasmid-mediated drug resistance also occurs by the production of extended-spectrum β-lactamases (ESBL), metallo β-lactamases (MBL), and AmpC β-lactamases. Another important factor for establishment of chronic infections by P. aeruginosa is biofilm formation mediated by the psl gene cluster.
objectivesThe aim of this study was to evaluate biofilm formation and presence of the pslA gene in burn isolates of P. aeruginosa as well as the association of antibiotic resistance, MBL, ESBL and AmpC β-lactamase production with biofilm formation among the isolates. MATERIALS AND
methodsSixty-two burn isolates of P. aeruginosa were obtained from Shahid Motahari Hospital in Tehran from August to October 2011. Antibiotic susceptibility was determined by the disc diffusion assay. MBL, AmpC and ESBL production were screened using the double disc synergy test, AmpC disc test and combined disc diffusion assay, respectively. The potential to form biofilm was measured using the microtiter plate assay and pslA gene was detected using specific primers and PCR.
resultsBiofilm formation was observed in 43.5% of the isolates, of which 66.7% produced strong and 33.3% formed weak biofilms. All biofilm-positive and 14.2% of biofilm-negative isolates harbored the pslA gene. MBL, AmpC and ESBL production were significantly higher in the biofilm-positive isolates (70.3%, 62.9% and 33.3%, respectively) compared to the biofilm-negative strains (31.4%, 34.2% and 20%, respectively). Overall, 19 isolates (30.6%) co-produced MBL and AmpC, among which the majority were biofilm-positive (63.1%). Finally, four isolates (6.4%) had all three enzymes, of which 3 (75%) produced biofilm.
conclusionsBiofilm formation (both strong and weak) strongly correlated with pslA gene carriage. Biofilm formation also correlated with MBL and AmpC β-lactamase production. More importantly, multiple-β-lactamase phenotype was associated with formation of strong biofilms.
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