ArticleJundishapur journal of microbiology2015
Hepatitis B virus Genotyping Among Patients With Cirrhosis.
Article in Jundishapur journal of microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Natural History of Chronic Hepatitis B Virus Infection in Ahvaz City, IranAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Update on occult hepatitis B virus infection.World journal of gastroenterology · 2016Review
- Predictive Factors in the Incidence of Cirrhosis in Chronic Hepatitis B Virus Infections.Hepatitis monthly · 2016Article
- Positive Expression of Human Cytomegalovirus Phosphoprotein 65 in Atherosclerosis.BioMed research international · 2016Article
- Association between interleukin-10 gene promoter polymorphisms and susceptibility to liver cirrhosis.International journal of clinical and experimental pathology · 2015Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHepatitis B virus (HBV) infection is a worldwide public health problem. Nine HBV genotypes (A-I) have been already discovered. HBV genotypes are important both in the clinical manifestation of disease and treatment response. Moreover, HBV DNA without HBs (Hepatitis B surface)-antigenemia was detected in some patients with chronic hepatitis (occult hepatitis). There is little information about HBV genotypes and its relation to occult infection despite the importance of this infection in Khuzestan Province.
objectivesThis study aimed to determine both occult hepatitis B infection and HBV genotypes among cirrhotic patients. PATIENTS AND
methodsThirty-eight patients with liver cirrhosis, including 11 (28.9%) HBsAg-positive patients and 27 (71.1%) patients with cryptogenic cirrhosis participated in this study. The mean age of the patients at the time of cirrhosis diagnosis was 54.85 years (range 26-75 years). All patients were anti-HCV and anti-HIV negative. For all the samples, the serological Enzyme-Linked Immunosorbent Assay (ELISA) was performed for HBV markers including HBsAg, HBcAb, HBeAg, HBeAb tests. The common primer of S region of HBV was used for Nested PCR. The PCR products of the positive individuals were sequenced for genotyping and subtyping of HBV.
resultsEleven (40.7%) out of 27 HBV cryptogenic cirrhosis and all 11 HBsAg-positive patients were positive for HBV DNA. The seroprevalences of Hepatitis B virus HBe antigen, anti-HBe and anti-HBc antibodies among the cryptogenic cirrhosis patients were 5 (18.5%), 1 (3.7%), and 5 (20.83), and among HBsAg-positive patients were 6 (54.5%), 5 (45.5%), and 7 (63.6%), respectively.
conclusionsIn our study, only HBV genotype D was found among all the positive HBsAg and occult HBV infection. Moreover, high prevalence (40.7%) of occult HBV infection was determined among patients suffered from cryptogenic cirrhosis.
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