ArticleFrontiers in integrative neuroscience2015
Neurons in red nucleus and primary motor cortex exhibit similar responses to mechanical perturbations applied to the upper-limb during posture.
Article in Frontiers in integrative neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
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- Reactive and Proactive Adaptation of Cognitive and Motor Neural Signals during Performance of a Stop-Change Task.Brain sciences · 2021Review
- Red nucleus structure and function: from anatomy to clinical neurosciences.Brain structure & function · 2021Review
- Neural Signals in Red Nucleus during Reactive and Proactive Adjustments in Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Long-latency Responses to a Mechanical Perturbation of the Index Finger Have a Spinal Component.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Degradation of Praxis Brain Networks and Impaired Comprehension of Manipulable Nouns in Stroke.Journal of cognitive neuroscience · 2020Article
- Corticospinal excitability of tibialis anterior and soleus differs during passive ankle movement.Experimental brain research · 2019Article
- Mechanical perturbations can elicit triggered reactions in the absence of a startle response.Experimental brain research · 2018Article
- Immunohistochemical localization of ionotropic glutamate receptors in the rat red nucleus.Bosnian journal of basic medical sciences · 2017Article
- Long-latency reflexes of elbow and shoulder muscles suggest reciprocal excitation of flexors, reciprocal excitation of extensors, and reciprocal inhibition between flexors and extensors.Journal of neurophysiology · 2016Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary motor cortex (M1) and red nucleus (RN) are brain regions involved in limb motor control. Both structures are highly interconnected with the cerebellum and project directly to the spinal cord, although the contribution of RN is smaller than M1. It remains uncertain whether RN and M1 serve similar or distinct roles during posture and movement. Many neurons in M1 respond rapidly to mechanical disturbances of the limb, but it remains unclear whether RN neurons also respond to such limb perturbations. We have compared discharges of single neurons in RN (n = 49) and M1 (n = 109) of one monkey during a postural perturbation task. Neural responses to whole-limb perturbations were examined by transiently applying (300 ms) flexor or extensor torques to the shoulder and/or elbow while the monkeys attempted to maintain a static hand posture. Relative to baseline discharges before perturbation onset, perturbations evoked rapid (<100 ms) changes of neural discharges in many RN (28 of 49, 57%) and M1 (43 of 109, 39%) neurons. In addition to exhibiting a greater proportion of perturbation-related neurons, RN neurons also tended to exhibit higher peak discharge frequencies in response to perturbations than M1 neurons. Importantly, neurons in both structures exhibited similar response latencies and tuning properties (preferred torque directions and tuning widths) in joint-torque space. Proximal arm muscles also displayed similar tuning properties in joint-torque space. These results suggest that RN is more sensitive than M1 to mechanical perturbations applied during postural control but both structures may play a similar role in feedback control of posture.
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