ArticleThe journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
Metabolic and hormonal effects of antenatal betamethasone after 35 weeks of gestation.
Article in The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03076775 (Fetal Metabolic Consequences of Late Preterm Steroid Exposure), which is not on this map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Fetal Metabolic Consequences of Late Preterm Steroid Exposure
Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Metformin, Maternal Glycemic Control, and Neonatal Hypoglycemia After Antenatal Steroids: A Randomized Clinical Trial.JAMA network open · 2026Trial
- Euglycemia after antenatal late preterm steroids: a multicenter, randomized controlled trial.American journal of obstetrics & gynecology MFM · 2022Trial
- An encyclopedia of the cord blood metabolome reveals maternal-fetal interactions and disease risk.Cell reports. Medicine · 2026Article
- [Impact of antenatal corticosteroids on respiratory morbidities in late preterm infants born to mothers with gestational diabetes mellitus].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Article
- The impact of antenatal corticosteroids on respiratory and metabolic outcomes in late-preterm births depends on timing, number of courses, and singleton/twin status: a retrospective cohort study.BMC pregnancy and childbirth · 2026Article
- S100-alarmins, antenatal corticosteroids and the risk of late-onset sepsis in preterm infants: A prospective cohort study.PloS one · 2026Article
- Betamethasone latency period and neonatal hypoglycemia in term infants.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2025Article
- Antenatal corticosteroid treatment after 34 weeks of gestation in twin pregnancies at high risk of late preterm delivery.BMC pregnancy and childbirth · 2025Article
- Maternal and neonatal outcomes following antenatal corticosteroids in pregnancies complicated by diabetes: a scoping review.AJOG global reports · 2024Article
- The effect of time interval between antenatal corticosteroid administration and delivery on outcomes in late preterm neonates born to mothers with diabetes: a retrospective cohort study.Frontiers in pediatrics · 2023Article
- Time Interval From Early-Term Antenatal Corticosteroids Administration to Delivery and the Impact on Neonatal Outcomes.Frontiers in pediatrics · 2022Article
- Antenatal Corticosteroids and Preterm Neonatal Morbidity and Mortality among Women with and without Diabetes in Pregnancy.American journal of perinatology · 2022Article
- Antenatal dexamethasone use and respiratory distress in late preterm infants: results from first Vietnamese matched cohort study.BMC pregnancy and childbirth · 2021Article
- Does antenatal steroids treatment in twin pregnancies prior to late preterm birth reduce neonatal morbidity? Evidence from a retrospective cohort study.Archives of gynecology and obstetrics · 2020Article
- Neonatal hypoglycemia after initiation of late preterm antenatal corticosteroids.Journal of perinatology : official journal of the California Perinatal Association · 2020Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAntenatal corticosteroid therapy recently has been considered for term and near-term infants, in addition to preterm infants, delivered by elective cesarean section, with the aim of preventing an adverse respiratory outcome.
objectivesThe objective of this study was to investigate hormonal and metabolic effects of antenatal betamethasone when administered to term fetuses.
methodsCord blood levels of cortisol, C-peptide, insulin-like growth factor I and its binding protein 3, and 5 more analytes including glucose were measured in singleton newborns of over 35 weeks of gestational age. In anticipation of a cesarean delivery, the mother was either treated or not treated with 12 mg of intramuscularly administered antenatal betamethasone approximately 24 hours prior to birth. Babies of comparable gestational age, sex, and nutritional status who were not treated antenatally served as controls.
resultsCord serum cortisol levels of the betamethasone-treated fetuses were suppressed to <10% of that of untreated controls (median levels of 11.6 nmol/L vs. 138.2 nmol/L, respectively), and their C-peptide and glucose levels were significantly higher (2.85 mcg/L vs. 1.19 mcg/L, respectively, p < 0.0001; and 62.5 mg/dL vs. 56.0 mg/dL, respectively, p = 0.01).
conclusionsProphylactic betamethasone therapy causes immediate hormonal alterations, which might interfere with the metabolic adaptation of the newborn. This issue deserves thorough investigation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.